Objective: To explore effects of Jiangtang Xiaozhi (JTXZ) tablets for improving insulin resistance and decreasing blood lipids. Method: Wistar rat model with insulin resistance was established by taken high fat feed for one month. Thereafter

seventy rats were randomly and equally assigned to 7 groups (10 rats/group)

including a normal control group with common-feed

a model group with high fat feed and without any treatment

two positive control groups by treatment of Pioglitazone Hydrochloride tablets(5 mg·kg-1)and simvastatin tablets (4 mg·kg-1)

and three JTXZ tablets groups at dose of 8

4

2 g·kg-1

by received intragastric administration daily for 2 months concurrently continued to take high fat feed. Total cholesterol (TC)

triglyceride (TG)

high density lipoprotein-cholesterol(HDL-C)

low density lipoprotein-cholesterol(LDL-C)

super oxide dismutase(SOD)

malonic dialdehyde(MDA) and free fatty acids(FFA) were measured following glucose infusion rate (GIR) and euglycemic clamp test. The liver and pancreas were weighted to calculate the viscera index and performed pathological slice up for observation of morphological change. Result: GIR was significantly decreased in model group comparing to normal control group and indicating an obvious IR in model group. In comparison with model group

GIR was significantly increased in JTXZ tablets groups at dose of 8

4 g·kg-1 and indicating a noted improvement of IR; serum TC levels were markedly decreased in JTXZ tablets group at dose of 8 g·kg-1; serum TG levels were also significantly reduced in JTXZ tablets groups with all doses; serum HDL-C levels was evidently enhanced and serum LDL-C levels was significantly reduced in JTXZ tablets group at dose of 8 g·kg-1; SOD activities were markedly increased and MDA were notedly decreased in JTXZ tablets groups at all doses; the liver index was reduced in JTXZ tablets group at dose of 8 g·kg-1. The pathological observation indicated morphological improvement of liver and pancreas at various degrees in JTXZ tablets groups at all doses compared with model group. Conclusion: JTXZ tablets have obvious effects on improving insulin resistance and decreasing blood lipids.