Neuroprotective Effects of Paeoniflorin on Multi-infarct Dementia (MID) Model

LI Xiao-yu; SUN Rong; REN Hai-yong; OUYANG Bing

doi:10.11653/syfj2013240230

您当前的位置：

首页 >

文章列表页 >

Neuroprotective Effects of Paeoniflorin on Multi-infarct Dementia (MID) Model

更新时间：2024-01-04

- Neuroprotective Effects of Paeoniflorin on Multi-infarct Dementia (MID) Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 24, Pages: 230-235(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013240230
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
LI Xiao-yu, SUN Rong, REN Hai-yong, et al. Neuroprotective Effects of Paeoniflorin on Multi-infarct Dementia (MID) Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 230-235.
DOI：

LI Xiao-yu, SUN Rong, REN Hai-yong, et al. Neuroprotective Effects of Paeoniflorin on Multi-infarct Dementia (MID) Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 230-235. DOI： 10.11653/syfj2013240230.

摘要

目的：用改良多梗塞性脑痴呆（multi-infarct dementis，MID）模型，观察芍药苷对MID模型大鼠保护作用与路径，为开发神经原保护剂的候选化合物奠定药理学基础。方法：建立大鼠MID模型，观察剂量分别为20，10，5 mg·kg-1的芍药苷对MID大鼠的保护作用并观察行为学及认知功能，用免疫组织化学检测不同脑组织内Bcl-2，Bax蛋白表达，用HE染色和电镜观察大脑皮层及神经元结构变化。结果：假手术组无神经行为改变，与假手术组相比，MID模型组大鼠的苏醒时间、神经行为学评价、斜扳试验、学习记忆等认知功能障碍和脑组织神经元均受影响，与模型组相比，各用药组大鼠的苏醒时间、神经行为学评价、斜扳试验、学习记忆等认知功能障碍和脑组织神经元均有明显改善。结论：芍药苷可改变MID大鼠的神经行为，对大鼠MID模型有明显的改善作用，抑制Bax表达，促进Bcl-2的表达，有抗神经元凋亡的作用。

Abstract

Objective: To establish the improved multi-infarct dementia (MID) model

and observe the protective effect and pathway of paeoniflorin on MID model rats. Method: The classic rat's MID model was used to observe protective effect and pathway of different doses of paeoniflorin. The learning and memory abilities of rats were detected by Morris water maze. The expressions of Bcl-2 and Bax protein were detected by immunohistochemical.The changes of cerebral cortex and the neuron structure were detected by HE staining and electron microscopy. Result: The control group had no behavior change. The nerve behavior evaluation

oblique pull test

learning and memory and Brain neurons were affected compared withthe sham-operation group.But the nerve behavior evaluation

oblique pull test

learning and memory and Brain neurons were all significantly improved compared with model group

the expression of Bcl-2 was increased and Bax was restrained. Conclusion: The paeoniflorin has significant improvement effect on the rats' MID model

So its protective mechanism is related with the Bcl-2 and Bax protein expression.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Paeoniflorin Induces Apoptosis in NSCLC Cells via Activating Hippo Signaling Pathway

Protective Mechanism of Paeoniflorin on Mice with Ulcerative Colitis Based on AMPK/mTOR Autophagy Pathway

Chemical Constituents and Pharmacological Effects of Paeoniae Radix Rubra： A Review

Analysis on Quality Transmitting of Substance Benchmarks of Shaoyao Gancaotang

Protective Effect of Ferulic Acid on PC12 Cells with H₂O₂-induced Oxidative Damage

Related Author

LI Yan

PENG Liang

JIANG Lifeng

WANG Sheng

WANG Ge

YU Xiaolin

YAO Yulin

DAI Xin

Related Institution

Henan University of Chinese Medicine

Fuwai Central China Cardiovascular Hospital/Henan Provincial People's Hospital

The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital

School of Clinical Medicine，Changchun University of Chinese Medicine

School of Pharmacy，Changchun University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰