Effects of Naomai Shukang Capsule on Mice Acute Cerebral Ischemia Model

BAI Ming; LIU Dan-dan; WANG Can; GENG Xin-sheng; MIAO Ming-san

doi:10.11653/syfj2013240255

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Effects of Naomai Shukang Capsule on Mice Acute Cerebral Ischemia Model

更新时间：2024-01-04

- Effects of Naomai Shukang Capsule on Mice Acute Cerebral Ischemia Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 24, Pages: 255-257(2013)
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- DOI：10.11653/syfj2013240255
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- Published：2013
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BAI Ming, LIU Dan-dan, WANG Can, et al. Effects of Naomai Shukang Capsule on Mice Acute Cerebral Ischemia Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 255-257.
DOI：

BAI Ming, LIU Dan-dan, WANG Can, et al. Effects of Naomai Shukang Capsule on Mice Acute Cerebral Ischemia Model[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 255-257. DOI： 10.11653/syfj2013240255.

摘要

目的：探讨脑脉舒康胶囊（NMSKC）对小鼠脑缺血模型的影响。方法：采用昆明种小鼠，分为脑脉舒康胶囊组（4.0，2.0，1.0 g·kg-1）、模型对照组、阳性药（华佗再造丸2.67 g·kg-1，尼莫地平0.02 g·kg-1）对照组，各组连续灌胃9 d，于第10天给药1 h后，快速断头法制备小鼠急性全脑缺血模型，记录小鼠的喘息次数和喘息维持时间，取小鼠脑组织测定丙二醛（MDA）、乳酸（LD）的含量和超氧化物歧化酶（SOD）、乳酸脱氢酶（LDH）的活力。结果：脑脉舒康胶囊可以明显增加断头小鼠的呼吸次数及延长呼吸持续时间，并可降低MDA和LD含量，提高SOD和LDH的活力。结论：脑脉舒康胶囊对小鼠脑缺血机体有一定的保护作用。

Abstract

Objective: To investigate the effects of Naomai Shukang capsule(NMSKC)on mice acute cerebral ischemia model. Method: Kunming mice were divided into six groups:Naomia Shukang capsule groups(4.0

2.0

1.0 g·kg-1)

model control group

positive medicine control groups(Huatuo Zaizao pill 2.67 g·kg-1

Nimodipine 0.02 g·kg-1).The mice acute cerebral ischemia model was established by rapid head-breaking method

and recorded the respiratory frequency and duration

the brain tissue was collected foe measurement of the contents of lactic acid (LD)

lactic dehydrogenase (LDH)

malondiadehyde (MDA) and superoxide dismutase (SOD)activity. Result: Naomai Shukang capsule could significantly increase respiratory rate and prolong respiratory and reduce the contents of LA and MDA

and increase the activities of LDH and SOD in brain tissue. Conclusion: Naomai Shukang capsule has protective effects on acute cerebral ischemia injury in mice.

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