Objective: To study the influences of Fufang Jiangzhi capsule(FFJZ) on inflammatory factor in blood of rats with experimental atherosclerosis. Method: Twenty-five male SD rats and 25 female SD rats were given high diet (4% cholesterol

0.5% sodium tauroglycocholate

0.2% propylthiouracil

10% lard

85.3% ordinary diet)

then the rat AS model was established by injuring right common carotid artery and intramuscular injection of Vitamin D3.The rats were randomly divided into five groups as follows:model group (saline)

positive group (lovastatin 7.48 mg·kg-1)

FFJZ high dose group (53.34 g·kg-1)

FFJZ medium dose group (26.67 g·kg-1)

low dose group (13.33 g·kg-1)

respectively

while control group (10 rats) was given ordinary diet. The cupsules were given by oral administration once a day

after that

specimens of blood and right common carotid artery were collected

indications including blood-lipid

Interleukin-6(IL-6)

Interleukin-10(IL-10) and tumor necrosis factor-a(TNF-α)were examined along with histopathology studies and observation of the change of artery walls with microscopy. Result: After the intervention treatment of the capsule

the concentrations of triglyceride (TG)

total cholesterol (TC)

low density lipoprotein cholesterol (LDL-C)

IL-6 were decreased while the concentrations of high density lipoprotein cholesterol (HDL-C)

IL-10 and TNF-α were increased. The formation of arterial wall plaque was reduced;the deposits of foam cells and lipid were shorten. Conclusion: FFJZ could dramatically decrease the concentrations of lipid in serum and reduce risk of the formation of AS plaque. The mechanism could be associated with the inflammation inhibition

protecting the function of vascular endothelial cells and suppressing the formation of AS plaque.