Effects of Compound Notogin Sengnano Granules on Blood Brain Barrier, Tumor Necrosis Factor- and Interleukin-6 after Brain Injury in Rats

WANG Zhu; ZhAO Ya-Ning; LI Jian-min; HUANG Hai-ling; LIU Wen-qian

doi:10.11653/syfj2013240270

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Effects of Compound Notogin Sengnano Granules on Blood Brain Barrier, Tumor Necrosis Factor- and Interleukin-6 after Brain Injury in Rats

更新时间：2024-01-04

- Effects of Compound Notogin Sengnano Granules on Blood Brain Barrier, Tumor Necrosis Factor- and Interleukin-6 after Brain Injury in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 24, Pages: 270-273(2013)
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- DOI：10.11653/syfj2013240270
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- Published：2013
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WANG Zhu, ZhAO Ya-Ning, LI Jian-min, et al. Effects of Compound Notogin Sengnano Granules on Blood Brain Barrier, Tumor Necrosis Factor- and Interleukin-6 after Brain Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 270-273.
DOI：

WANG Zhu, ZhAO Ya-Ning, LI Jian-min, et al. Effects of Compound Notogin Sengnano Granules on Blood Brain Barrier, Tumor Necrosis Factor- and Interleukin-6 after Brain Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(24): 270-273. DOI： 10.11653/syfj2013240270.

摘要

目的：观察复方三七纳米颗粒对脑创伤后大鼠血脑屏障、肿瘤坏死因子-α（TNF-α）和白介素-6（IL-6）的影响作用。方法：用Feeney自由落体撞击法建立成年雄性大鼠脑创伤模型，96只实验动物随机分为空白对照组、创伤模型组、复方三七纳米颗粒低、高剂量组（0.6，2.4 g·kg-1），每组24只大鼠。第1，3，5天参照ZeaLonga法，对各组实验大鼠进行神经功能缺损评分；之后经腹主动脉穿刺取血，用双抗体夹心酶联免疫吸附法（ELISA）测量各组不同时间点大鼠（n=8）血清肿瘤坏死因子-α（TNF-α）和白介素-6（IL-6）含量的变化；之后处死大鼠，取造模损伤部位脑组织（约4 mm×4 mm×3 mm）称重计算脑组织含水量，观察用药后各时间点大鼠脑水肿情况。结果：与空白对照组比较，模型组神经功能缺损评分升高，脑组织含水量、TNF-α和IL-6含量均增加；与模型组比较，复方三七纳米颗粒干预组中神经功能缺损评分降低，脑组织含水量、TNF-α和IL-6含量均降低，并且随着剂量的增加上述变化显著（P<0.05）。结论：复方三七纳米颗粒对大鼠脑创伤后有保护作用，与TNF-α的含量降低和IL-6含量增加有关。

Abstract

Objective: To investigate the effects of the compound Notogin Sengnano granules on blood brain barrier

tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in rats after traumatic brain injury. Method: The trauma model were established according to the Feeney free-fall impact brain injury using adult male rats.The nine-six rats were divided into four groups:control group

model group

low-dose compound Notogin Sengnano granules group(0.6 g·kg-1)and high-dose compound Notogin Sengnano granules group(2.4 g·kg-1). The rats in each group were scored according to the ZeaLonga neural function score.At the 1

5 d

blood samples were collected to detect detect(TNF-α) and IL-6 by ELISA.The brain tissue were collected for determination of water content. Result: Compared with control group

in model group the neural function defect score was increased

the brain water contents significantly increased

the contents of TNF-α and IL-6 content were increased. Compared with model group

in compound Notogin Sengnano gragules group

the neural function defect score

the brain water contents

TNF-α and IL-6 levels were decreased

significantly decreased(P<0.05). Conclusion: The compound Notogin Sengnano granules can promote the recovery of neural function and reduce the content of the TNF-α and IL-6 in rats after the traumatic brain injury.

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Related Institution

Heilongjiang University of Chinese Medicine， Institute of Traditional Medicine

The Second Clinical Medical College， Guizhou University of TCM

Graduate School of Guizhou University of Traditional Chinese Medicine（TCM）

Key Laboratory for Chinese Internal Medicine Co-constructed by Ministry of Education and Beijing Municipality, Dongzhimen Hospital, Beijing University of Chinese Medicine

Shanxi University of Chinese Medicine

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