Objective: To compare toxicities of Taxillus sutchuenensis from different hosts. Method: Acute toxicities were tested on T. sutchuenensis from six different host plants by measuring median lethal dose (LD50) or maximum tolerance dose (MTD). And on the bais of different hosts

ninety-eight mice were randomly divided into seven groups:the normal group

the Pyrus pyrifolia group

the P. salicina group

the Populus canadensis group

the Xylosma japonicum group

the Nerium indicum group

the Toxicodendron vernicifluum group. Except for normal group

the other mice were orally administered corresponding aqueous extracts 7.5 g·kg-1 once per day for four weeks. The indexes of serum alanine aminotransferase (AST)

aspartate aminotransferase (ALT) and creatinine (Cr)

urea nitrogen (BUN) were determined for evaluation. And the morphological changes of liver tissue and nephridial tissue were observed. Result: Herbs from N. indicum and T.vernicifluum were apparently toxicant. The one from N. indicum LD50 was 109.276 g·kg-1

with 95% confidence limit of 96.837-122.645 g·kg-1

and the other from T.vernicifluum LD50 was 77.286 g·kg-1

with 95% confidence limit of 66.891-89.296 g·kg-1. Herbs from other four hosts has no mice death. Compared with control group

T. sutchuenensis from N. indicum could raise mice's Cr index

and harmed their kidney but not obvious of other hosts. Conclusion: T. sutchuenensis from toxic hots were poisonous.