Objective: The study the influence of Bushen Tiaopi fang on female climacteric syndrome (CS) glucolipid metabolism And endocrine level. Method: Eighty cases of CS patients were randomly divided into control group (40 cases) and observation group (40 cases) according to digital method. The patients in both groups took appropriate psychological counseling treatment and guidance on diet and exercise. Patients in control group took Tibolone Tablets

2.5 mg/time

1 time/day

orally. Patients in observation group took Bushen Tiaopi fang

1 dose/day

2 times/day

conventional water frying

treatment course 12 weeks. The KI scores of before and after the treatment of 4

8 and 12 weeks were recorded. Levels of serum estradiol (E2)

follicle-stimulating hormone (FSH)

luteinizing hormone (LH)

serum triglyceride (TG)

total cholesterol (TC)

high-density lipoprotein (HDL-C) and low density lipoprotein (LDL-C) were detected before and after the treatment. The height

weight

waist circumference and hip circumference were measured

calculating body mass index (BMI) and waist-hip ratio (WHR). Fasting blood glucose (FBG) and fasting insulin (FINS) were detected

calculating the homeostasis insulin rate (HOMA-IR). Levels of serum Leptin (LP) and Adiponectin (APN) were measured. Result: The total effects of the observation group and control group were 92.5% and 87.5% respectively

which means no statistical significance from the differences between two groups. After the treatment

KI scores of two groups were significantly decreased

which also means no statistical significance from the differences between two groups at different points. E2 levels of two groups increased dramatically

which shows no statistical significance from differences between groups. Levels of FSH and LH significantly decreased after treatment

which shows no statistical significance from differences between groups. BMI and WHR of observation group were significantly decreased after the treatment and were lower than the control group (P<0.05). TG

TC and LDL-C of observation group were decreased after the treatment and were lower than the control group (P<0.05 or P<0.01). HDL-C of observation group increased apparently and was higher than the control group (P<0.01). After treatment

FBG

FINS and HOMA-IR of observation group all reduced

which were lower than the control group (P<0.05 or P<0.01). Serum LP level of observation group was lower than the control group

while APN level was higher than the control group (P<0.01). Conclusion: Bushen Tiaopi fang can improve the clinical symptoms and CS endocrine levels of CS patients

which has the similar effect as Tibolone Tablets. Bushen Tiaopi fang can also regulate glycolipid metabolism of CS patients.Its mechanism may be associated with increasing serum APN and decreasing LP level.