Objective: To investigate the clinical effect of Runzao Zhiyang capsule combined with desloratadine in the treatment of senile skin pruritus. Method: This study in 2012 February-2013 year in February admitted to the senile pruritus patients with Runzaozhiyang capsule combined with desloratadine in the treatment and control group. Result: The total effective rate in treatment group was higher than that of control group

and the difference was statistically significant (P<0.05). In the treatment group patients improved significantly in terms of pruritus

frequency

duration

consciously itching severity

extent

dry skin lesions (P<0.05). In two groups patients during treatment did not appear systemic allergic rash and general discomfort and other adverse reactions.Six cases in the treatment group occurred skin flushing

with no burningand dryness. In the control group the occasional sleepiness

fatigue

dry mouth

but the symptom were slightr. Conclusion: The clinical effect of Runzao Zhiyang capsule combined with desloratadine in the treatment of senile skin pruritus is accurate

no serious adverse reaction was found

and it is worthy of clinical application