Preparation and  Release of Matrine Gels

XU He; DAI Ling; SHEN Cheng-ying; BAI Jin-xia; SHEN Bao-de; YUAN Hai-long

doi:10.11653/syfj2014010008

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Preparation and Release of Matrine Gels

更新时间：2024-01-04

- Preparation and Release of Matrine Gels
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 1, Pages: 8-11(2014)
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- DOI：10.11653/syfj2014010008
  CLC：
- Published：2014
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XU He, DAI Ling, SHEN Cheng-ying, et al. Preparation and Release of Matrine Gels[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 8-11.
DOI：

XU He, DAI Ling, SHEN Cheng-ying, et al. Preparation and Release of Matrine Gels[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 8-11. DOI： 10.11653/syfj2014010008.

摘要

目的：优选苦参碱凝胶剂的处方工艺并考察其体外释药特性。方法：采用HPLC测定苦参碱含量，流动相乙腈-0.02 mol·L-1磷酸二氢钾溶液（6：94），检测波长210 nm。利用动态透析法测定苦参碱凝胶剂体外释放率，以1，5，10 h累计释放率的综合评分为指标，通过正交试验考察卡波姆-940用量、苦参碱用量、氮酮用量及凝胶pH对处方工艺的影响。结果：优选的处方工艺为卡波姆-940、苦参碱和氮酮用量分别为1.0，2.0，0.5 g，pH调节至6.8；苦参碱凝胶剂在1，5，10 h内的体外累计释放率分别为（10.17±0.35）%，（74.90±0.70）%，（94.53±0.74）%。结论：优选的处方工艺稳定可行，制备的苦参碱凝胶剂具有缓释特性。

Abstract

Objective: To optimize formulation process of matrine gels and evaluate its in vitro release characteristics. Method: The content of matrine was measured by HPLC

mobile phase of acetonitrile-0.02 mol·L-1 potassium dihydrogen phosphate solution(6:94)

detection wavelength 210 nm.Dynamic dialysis method was adopted to determine in vitro release rate of matrine gels

taking composite score of cumulative release rates at 1

10 h as index

orthogonal test was applied to optimize formulation process with amounts of carbomer-940

matrine and azone

gels pH as factors. Result: Optimized formulation process of matrine gels was obtained

dosages of carbomer-940

matrine and azone were 1.0

2.0

0.5 g

respectively;Gels pH was adjusted to 6.8 eventually.In vitro cumulative release rate at 1

10 h were(10.17±0.35)%

(74.90±0.70)% and (94.53±0.74)%

respectively. Conclusion: This optimized process was simple and feasible

these prepared matrine gels had sustained release properties.

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