Quality Standard of  in Qingshen Granule

SHI Jin-min; GAO Jia-rong; JIA Lu; LI Rao-rao; GU Xue-zhu

doi:10.11653/syfj2014010063

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Quality Standard of in Qingshen Granule

更新时间：2024-01-04

- Quality Standard of in Qingshen Granule
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 1, Pages: 63-65(2014)
- 作者机构：
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- DOI：10.11653/syfj2014010063
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- Published：2014
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SHI Jin-min, GAO Jia-rong, JIA Lu, et al. Quality Standard of in Qingshen Granule[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 63-65.
DOI：

SHI Jin-min, GAO Jia-rong, JIA Lu, et al. Quality Standard of in Qingshen Granule[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 63-65. DOI： 10.11653/syfj2014010063.

摘要

目的：建立清肾颗粒中白花蛇舌草的质量控制标准。方法：采用薄层色谱法对制剂中的白花蛇舌草进行定性鉴别，采用高效液相色谱法测定制剂中白花蛇舌草的去乙酰车叶草酸甲酯的含量。色谱条件：Kromasil C18色谱柱（4.6 mm×250 mm，5 μm），流动相乙腈-水（3.5：96.5），流速1.0 mL·min-1，检测波长236 nm。结果：薄层色谱清晰，阴性无干扰，重复性良好，去乙酰车叶草酸甲酯在0.042~1.35 4 μg呈良好的线性关系（r=1.000 0）平均回收率99.96%（RSD 1.66%）。结论：该方法可操作性强，重复性好，可用于清肾颗粒中白花蛇舌草的质量控制。

Abstract

Objective: To study on quality standard of Olden landia diffusa in the Qingshen granule. Method: Thin-layer chrmatography was used to identidy O. landia diffusa. The content of deacetyl asperulosidicacid methyl ester was determined by HPLC. The HPLC consisted of Kromasil C18 (4.6 mm×250 mm

5 μm)

acetonitrile-water (3.5:96.5) as mobile phase

flow rate of 1.0 mL·min-1

detection wavelength at 236 nm. Result: The study on the quality control showed that the characteristic of identification by HPLC was distinct

accurate and reproducible.The linear range of deacetyl asperulosidicacid methyl ester was 0.042-1.35 4 μg(r=1.000 0). the average recovery was 99.96% with RSD of 1.66%. Conclusion: The methods are accurate and quick in qualitative identification and quantitative assay of this preparation

can be used for the quality control of Qingshen granule.

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Related Author

SHI Jin-min

WEI Liang-bin

LI Rao-rao

JIA Lu

ZHANG Zhi-jie

GU Xue-zhu

XU Fuyu

LUO Hongbing

Related Institution

中国中医学科学院中药研究所

郑州大学药学院

安徽中医学院第一附属医院,安徽中医学院第一附属医院,中国中医学科学院中药研究所,郑州大学药学院,中国中医学科学院中药研究所,中国中医学科学院中药研究所

Jiangxi University of Chinese Medicine

Jiangxi Institute of Quality and Standardization

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