Serum Pharmacochemistry of Shuxiong Tablets

LEI Zhi-dan; HUANG Ying; LEI Zhi-jun; XIA Xin-hua

doi:10.11653/syfj2014010077

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Serum Pharmacochemistry of Shuxiong Tablets

更新时间：2024-01-04

- Serum Pharmacochemistry of Shuxiong Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 1, Pages: 77-80(2014)
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- DOI：10.11653/syfj2014010077
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- Published：2014
- 稿件说明：
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LEI Zhi-dan, HUANG Ying, LEI Zhi-jun, et al. Serum Pharmacochemistry of Shuxiong Tablets[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 77-80.
DOI：

LEI Zhi-dan, HUANG Ying, LEI Zhi-jun, et al. Serum Pharmacochemistry of Shuxiong Tablets[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 77-80. DOI： 10.11653/syfj2014010077.

摘要

目的：对舒胸片进行血清药物化学研究。方法：采用SD大鼠灌胃给药，于给药一定时间后取血，测定复方及各单味药提取液血样的HPLC色谱图。采用Kromasl C18色谱柱，0.05%酸水-乙腈梯度洗脱，波长203 nm，流速1 mL·mL。结果：舒胸片血清HPLC指纹图谱中可检出15个成分，其中血清本身具的成分4个，其余11个可能来自复方的原成分及其代谢产物。舒胸片中已知的6种主要成分（川芎嗪、羟基红花黄花素A、阿魏酸、三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1）均可从血清中检出，表明为入血成分。在血清HPLC指纹图谱与复方HPLC指纹图谱的基础上，建立了舒胸片的表观血清指纹图谱。结论：所建立的舒胸片提取液HPLC指纹图谱测定方法操作简便，重复性好，可反映舒胸片药材中多成分的信息。

Abstract

Objective: To conduct serum pharmacochemistry study on extract in Shuxiong Tablets. Method: HPLC research on the serum fingerprints chromatograms of Shuxiong tablet extract was based on blood serum chemical pharmacy:After SD rats were administrated by gavage

samples were taken respectively after certain periods and measures were made on serum chromatograms of both mixed extracts and each single extract

then analysis is made. An HPLC method was adopted with column Kromasil C18(4.60 mm×200 mm

5 μm ).The mobile phase was consisted of 0.05%phosphoric acid-water-acetonitrilegradient elution. The flow velocity was 1.0 mL·min－1. The detection wavelength was at 203 nm. Result: Fifteen components were detected in the fingerprint serum

4 come from the original compound and their metabolites. The 6 known major components of Shuxiong tablet (ligustazine

hydroxysafflor yellow A

ferulic acid

notoginsenoside R1

ginsenoside Rg1

ginsenoside Rb1) which showed that they were elements in the blood. The serum chromatograms of Shuxiong tablet were established on the basis of serum HPLC fingerprint chromatograms and compound HPLC fingerprint chromatograms. Conclusion: The measure of HPLC fingerprint chromatograms is simple and reproducible

and the fingerprint chromatograms can reflect multi-ingredients in the Shuxiong tablet

therefore

this study provides a reliable method for the effective quality control of Shuxiong tablet

and prepares for in-depth study on the tablet.

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Related Institution

Jiangxi University of Chinese Medicine

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