SHI Xu-guang, WU Mei-yin, HUANG Man-ting, et al. Study of Buzhong Yiqi Decoction‘Yiqi Shengyang’Compatibility Mechanism Based on Metabonomics[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 103-106.
DOI:
SHI Xu-guang, WU Mei-yin, HUANG Man-ting, et al. Study of Buzhong Yiqi Decoction‘Yiqi Shengyang’Compatibility Mechanism Based on Metabonomics[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 103-106. DOI: 10.11653/syfj2014010103.
Study of Buzhong Yiqi Decoction‘Yiqi Shengyang’Compatibility Mechanism Based on Metabonomics
Objective: To study Buzhong Yiqi decoction‘Yiqi Shengyang' compatibility mechanism based on metabonomics. Method: The nuclear magnetic resonance spectroscopy (1H-NMR) was used to establish the rat serum metabolic fingerprinting techniques.The orthogonal partial least-squares discriminant was applied for analysis of metabolite profiling difference between model group and Buzhong Yiqi decoction group
increased Cimicifugae Rhizoma-Bupleuri Radix dosage group
Buzhong Yiqi without CⅡcifugae Rhizoma-Bupleuri Radix group
and through the variable importance in projection (VIP) biomarkers in serum were selected
the markers were compared to find the differences. Result: the moderating effect of Buzhong Yiqi decoction on spleen deficiency syndrome was reflected in the way of energy metabolism
glucose metabolism
lipid metabolism
amino acid metabolism regulation revision
while increased Cimicifugae Rhizoma-Bupleuri Radix dosage group
Buzhong Yiqi without Cimicifugae Rhizoma-Bupleuri Radix group improved three big nutrients metabolism to a certain extent in models group rats
but failed to restore the rat model' energy metabolism fundamentally
still in anaerobic respiration. Conclusion: Buzhong Yiqi decoction has adjustment effect on spleen deficiency of the strongest
mainly reflect in the recovery of amino acid metabolism and energy metabolism.
Overview on Application of Metabonomics in Research on Chinese Medicine Compound
Urine Metabonomics Analysis of Dried and Charred Zingiberis Rhizoma Recens on Rats with Deficiency-cold Hemorrhagic Disease
Urinary Metabonomic Study of Kidney-yang Deficiency Syndrome Induced by Hydrocortisone
Analysis of Urine Metabonomics of Nephrotic Syndrome Rats Treated with Compatibility of Tripterygii Wilfordii Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma Based on UPLC-Q-TOF-MS
Related Author
ZOU Zhong-jie
XIE Yuan-yuan
WANG Shu-mei
LIANG Sheng-wang
GUO Hui
CUI Yang
WANG Qiu-hong
KUANG Hai-xue
Related Institution
Guangdong Pharmaceutical University
Department of Chemistry,Tsinghua University
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School of Basic Medical Sciences, Guangzhou University of Chinese Medicine
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