ZHANG Jia-jia, YI Jing-li, ZHOU Yi-sheng, et al. Comparison of Pharmacokinetics Between Yufeng Ningxin Tablet and Disperible Tablets of Flavone[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 107-110.
DOI:
ZHANG Jia-jia, YI Jing-li, ZHOU Yi-sheng, et al. Comparison of Pharmacokinetics Between Yufeng Ningxin Tablet and Disperible Tablets of Flavone[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 107-110. DOI: 10.11653/syfj2014010107.
Comparison of Pharmacokinetics Between Yufeng Ningxin Tablet and Disperible Tablets of Flavone
Objective: To study and compare the serum concentration and pharmacokinetics of disperible tablets of Pueraria lobata flavone and Yufeng Ningxin tablet in rats. Method: The mice were given disperible tablets of Pueraria lobata flavone and Yufeng Ningxin tablet
HPLC was used to test the serum concentration at different time points and design conditions of pharmacokinetics by statistical software. Result: The Cmax of disperible tablets of Pueraria lobata flavone and merchant tablet was (20.21±0.18)
(9.90±0.25)mg·L-1. The dispersible tablet Tmax was (0.50±0.03) h
merchant tablet being (1.09±0.02) h. Conclusion: Disperible tablets of Pueraria lobata flavone has rapid absorbtion
the onset time was rapaid and the pharmacokinetics was superior to the control group.
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