RONG Zhen, WEI Hai-xia, CHEN Xin-ri, et al. Clinical Investigation of Bufei Xiaoji Decoction in Treatment of Patients with Advanced Drugs-resistant Non-small Cell Lung Cancer[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 173-177.
DOI:
RONG Zhen, WEI Hai-xia, CHEN Xin-ri, et al. Clinical Investigation of Bufei Xiaoji Decoction in Treatment of Patients with Advanced Drugs-resistant Non-small Cell Lung Cancer[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(1): 173-177. DOI: 10.11653/syfj2014010173.
Clinical Investigation of Bufei Xiaoji Decoction in Treatment of Patients with Advanced Drugs-resistant Non-small Cell Lung Cancer
Objective: To evaluate the curative effect and side-reactions of Bufei Xiaoji decoction in the treatment of patients with advanced drugs-resistant non-small cell lung cancer (NSCLC). Method: A total of 228 cases who suffered from failed treatment by first-line chemotherapy and possessed Qiyinl and phlegm stasis symptom were randomly divided into control group (114 cases) and treatment group (114 cases) from Ruikang hospital affiliated to Guangxi university of Chinese medicine. The control group accepted second-line chemotherapy for four weeks as a cycle
lasted two cycles. The treatment group was given Bufei Xiaoji decoction on basic treatment
for 4 weeks as a cycle
lasted two cycles. Result: One hundred and ninty-seven patients indicated clinical efficacy. In treatment group efficiency
the improvement rate of traditional Chinese medicine(TCM) symptom
CEA and CYFRA21-1 levels decreased
Ⅱ-Ⅳ degree white blood cell(WBC) and hemoglobin(HGB) reduced
gastrointestinal reactions
kidney damage incidence and one-year survival rate was superious to the control group (P<0.05);In Ⅱ-Ⅳ degree of thrombocytopenia and liver damage
there was no differences. Conclusion: Bufei Xiaoji decoction can improve the quality of life of the advanced drugs-resistant NSCLC
and enhance the clinical efficacy of chemotherapy and reduce chemotherapy toxicity
which suggests that Bufei Xiaoji decoction may have advantage in the reversal of lung tumor multidrug resistance.
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