Objective: To observe clinical effects of dialectical synthesis of Chinese medicine on severe cases hand-foot-mouth disease with complication of central nervous system damage and the influence of dialectical synthesis of Chinese medicine on neuron specific enolase (NSE). Method: Sixty subjects were randomly divided into observation group(n=30) and control group (n=30). Both groups were treated according toand ‘expert consensus’. Observation group were given ancient medicine Lingjiao Gouteng decoction and Changpu Yujin decoction on the basis of control group

for 10 days. The cases of body temperature returned to normal

blood picture back to normal

blood sugar back to normal

tremors disappear and mental health improvement in 3 days were recorded. The disappearing time of erythra

herpes and oral cavity ulcer healing time were recorded. Blood routine examination and blood glucose were monitored. Conventional and biochemical tests of cerebrospinal fluid and neuron specific enolase(NSE) test were proceeded in 0

5

10 days. Result: The cases of body temperature

blood picture

blood sugar back to normal in observation group were more than control group(P<0.05). Temperature returned to normal time

skittishness and tremors disappearing time

erythra

herpes disappearing time

oral cavity ulcer healing time and hemogram

blood glucose

cerebrospinal fluid returned to normal time in observation group were superior to control group(P<0.01). The total effective rate of observation group (93.3%) was superior to control group(73.3%)(P<0.05). The level of NSE and albumin in 5

10 days of both groups were declined than before(P<0.01)

the level of NSE and albumin in observation. Conclusion: The application of dialectical synthesis of Chinese medicine on patients with severe cases hand-foot-mouth disease with complication of central nervous system damage on the basis of conventional western medicine treatment can split-second control symptoms and signs of children

shorten the course of the disease

protect the children neural function

improve the clinical efficacy of therapy and it is worth using.