Objective: To investigate the effect of Astragal Polysaccharides combined with Iodine-125(I125)in the treatment of advanced non small cell lung cancer (NSCLC) clinical curative effect and mechanism of action. Method: A total of 60 cases of patients of advanced NSCLC were randomly by digital divided into observation group and control group with 30 cases in each group

the control group using I125 particle implantation method

the observation group was treated with Astragal Polysaccharide (APS) 250 mg

once a day. The course of treatment was 42 days. Before treatment in patients with tumor size

KPS score before and after treatment

the cell immune function were detected before and after treatment (NK

CD3+

CD4+

CD8+) and serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA-21-1) level. Result: after treatment

the observation group and the control group the total effective rate were 83.33% and 73.33%

no significant difference between the two groups;after treatment

the observation group KPS increase and stable rate were 90.0%

more than 63.3% of control group (P<0.01);the control group after treatment NK

CD3+

CD4+

CD8+ and CD4+/CD8+ did not change significantly

after treatment were observed in group NK

CD3+

CD4+ and CD4+/CD8+ increased and higher than that of the control group

CD8+ decreased and was lower than the control group(P<0.01);serum CEA

CYFRA-21-1 levels in the two groups were decreased than that before treatment

after treatment

the observation group than in the control group (P<0.01). Conclusion: APS combined with I125 in the treatment of advanced NSCLC

can improve the quality of life of patients

improve immune function

and has certain anti tumor effect and synergistic effect on the I125

worthy of further study.