Optimization of Molding Process for Dantao Granules

WU Jian-jun; LIU Xin; CHEN Li

doi:10.11653/syfj2014020008

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Optimization of Molding Process for Dantao Granules

更新时间：2024-01-04

- Optimization of Molding Process for Dantao Granules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 2, Pages: 8-10(2014)
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- DOI：10.11653/syfj2014020008
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- Published：2014
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WU Jian-jun, LIU Xin, CHEN Li. Optimization of Molding Process for Dantao Granules[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(2): 8-10.
DOI：

WU Jian-jun, LIU Xin, CHEN Li. Optimization of Molding Process for Dantao Granules[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(2): 8-10. DOI： 10.11653/syfj2014020008.

摘要

目的：优选丹桃颗粒的成型工艺。方法：以可溶性淀粉和糊精用量比、辅料用量和乙醇体积分数为自变量，合格颗粒收率、溶化性及临界相对湿度为因变量，采用星点设计-效应面法和总评归一值法优选丹桃颗粒的成型工艺。结果：最佳成型工艺条件为辅料-浸膏粉混合物用量比2：1，可溶性淀粉-糊精（1：1），润湿剂为75%乙醇；制备的颗粒剂合格收率约85%，溶化时间<1 min，临界相对湿度约58%。结论：优选的成型工艺稳定可靠，制备的丹桃颗粒具有合格率高、溶化性好、抗吸湿性强的特征，为丹桃颗粒的制备及生产环境控制提供实验依据。

Abstract

Objective: To optimize forming process of Dantao granules. Method: With ratio of soluble starch-dextrin

excipients consumption and ethanol concentration as independent variables

yield of qualified granules

dissolubility and critical relative humidity as dependent variables

forming process of Dantao granules was optimized by central composite design-response surface methodology and overall desirability method. Result: Optimal molding technology conditions were as follows:quality ratio of excipients-extract powder (2:1)

proportion between starch-dextrin (1:1)

with 75% ethanol as wetting agent;yield of qualified granules was about 85%

melting time was less than 1 min

critical relative humidity was about 58%. Conclusion: Optimized molding process was stable and reliable with high qualified rate

good dissolubility and strong anti-hygroscopicity

this research could provide basis for preparation and production environmental control of Dantao granules.

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Related Institution

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School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine (TCM)

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