Optimization of Preparation Technology of Andrographis Herba Extract--Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Methodology

LIU Ling; LI Xiao-fang; WEN Yi-jing; SHU Yu; WU Shan; LUO Li-jia

doi:10.11653/syfj2014020022

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Optimization of Preparation Technology of Andrographis Herba Extract--Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Methodology

更新时间：2024-01-04

- Optimization of Preparation Technology of Andrographis Herba Extract--Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 2, Pages: 22-25(2014)
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- DOI：10.11653/syfj2014020022
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- Published：2014
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LIU Ling, LI Xiao-fang, WEN Yi-jing, et al. Optimization of Preparation Technology of Andrographis Herba Extract--Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(2): 22-25.
DOI：

LIU Ling, LI Xiao-fang, WEN Yi-jing, et al. Optimization of Preparation Technology of Andrographis Herba Extract--Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(2): 22-25. DOI： 10.11653/syfj2014020022.

摘要

目的：采用星点设计-效应面法优化穿心莲提取物-β-环糊精（β-CD）包合物的制备工艺。方法：采用超声法制备穿心莲提取物-β-CD包合物，以包合率为评价指标，采用星点试验考察β-CD与穿心莲提取物的投料质量比、包合时间及包合温度对包合工艺的影响，对试验数据进行多元线性回归和二项式方程拟合，通过效应面法优选包合工艺条件并进行验证试验。结果：最佳包合工艺条件为β-CD与穿心莲提取物的投料质量比5.57：1，包合时间4.5 h，包合温度55 ℃；包合率预测值与理论值的偏差1.18%。结论：星点设计-效应面法适用于优化穿心莲提取物-β-CD包合物的制备工艺，建立的数学模型具有良好的预测性。

Abstract

Objective: To optimize preparation technology of Andrographis Herba extract-β-cyclodextrin(β-CD) inclusion complex by central composite design and response surface method. Method: Andrographis Herba extract-β-CD inclusion complex was prepared by ultrasonic method.Taking inclusion rate as index

central composite design test was adopted to optimize inclusion process with mass ratio of Andrographis Herba extract and β-CD

inclusion time and inclusion temperature as factors

test data were fitted by multi-linear equation and second-order polynomial equation

optimal inclusion technology was predicted by response surface method. Result: Optimum inclusion technology were as follows:mass ratio of Andrographis Herba extract and β-CD 5.57:1

inclusion time 4.5 h

inclusion temperature 55 ℃;Deviation between the observed value and the predicted value was 1.18%. Conclusion: Central composite design and response surface method was suitable for optimizing preparation technology of Andrographis Herba extract-β-CD inclusion complex

this established mathematical model had good predictability.

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Related Institution

Heilongjiang University of Chinese Medicine

Pharmacy College, Chengdu University of Traditional Chinese Medicine, Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, Key Laboratory of Systematic Research, Development and Utilization of Chinese Medicine Resources in Sichuan Province, Key Laboratory Breeding Base of Co-founded by Sichuan Province and Ministry of Science and Technology

Kaili University

School of Pharmacy, Heilongjiang University of Chinese Medicine

First Affiliated Hospital, Heilongjiang University of Chinese Medicine

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