Objective: To optimize prescription process of loquat flowers and leaves buccal tablet(LFLBT)and investigate its anti-inflammatory

eliminating phlegm and cough pharmacological activity by pharmacodynamic trials. Method: Taking taste and disintegration time as comprehensive evaluation index

orthogonal test was adopted to optimize prescription process of LFLBT with dosages of microcrystalline cellulose

aspartame

mannitol and citric acid as factors.Phenol red excretion method and concentrated ammonia spray induced cough method and xylene-induced ear swelling in mice method were applied to verifyanti-inflammatory

eliminating phlegm and cough activity of LFLBT. Result: The best prescription process was as follows:added 70 g of MCC

5 g of mannitol

0.5% of aspartame and 1% of citric acid into 30 g of aqueousextract of loquatflowers and leaves

and granulated with 95% ethanol as binder. Compared with blank group

high dose group of LFLBT could significantly increased excretion of phenol redand significantly inhibit ear swelling caused by xylene;Middle dose group and high dose group of LFLBT couldreduce frequency of cough in three minutes and prolong latent period of cough caused by ammonia water. Conclusion: Optimized prescription process was simple and feasible

prepared LFLBT had a certain activity of moisturizing throat.