Objective: To compare Hawthorn leaves extract niosomes and Yixintong tablet on pharmacodynamic actions of acute myocardial ischemia in rats

and provide the pharmacodynamics characteristics of Hawthorn leaves extract niosomes. Method: The rats were randomly divided into blank control group

model group

Yixintong tablet group

hawthorn leaf extract niosomes group

with 10 rats in each group. The rats of Yixintong tablet group and hawthorn leaf extract niosomes group were administered with 17.28 mg·kg-1 hawthorn leaf extract

once a day

for continuous 7 days;model group and blank control group rats were administered with equal volume of distilled water (10 mL·kg-1). On the 15th days and 16th day

except blank control group

other groups were ip 4.2 mg·kg-1 1 h after administration of isoproterenol

once a day

in order to establish the rat acute myocardial ischemia model

the rats in blank control group were ip equal volume of physiological saline. 24 h after establishing the model

1 h after the last administration

the rats were anesthetized with 10% chloral hydrate to obtain blood samples. Some myocardium enzymes like aspartic acid transferase (AST)

lactate dehydrogenase (LDH)

creatine phosphokinase (CPK)

malonyldialdehyde (MDA) and superoxide dismutase (SOD) were measured. Result: Compared with the blank control group

in model group the level of myocardium enzymes and MDA increased significantly (P<0.05)

the level of SOD was significantly decreased (P<0.001). Compared with model group

only the LDH and MDA levels in Yixintong group were significantly decreased(P<0.05)

AST

LDH

CPK

MDA levels in Hawthorn leaves extract niosomes group were significantly decreased(P<0.05 or P<0.01)

the level of SOD was significantly elevated(P<0.01). Compared with the Yixintong group

the AST

LDH

CPK

MDA levels in Hawthorn leaves extract niosomes group were no significant difference

the SOD level were significantly elevated(P<0.05). Hawthorn leaves extract niosomes in rat organs had no obvious toxicity. Conclusion: Hawthorn leaves extract niosomes and Yixintong tablets in clinical equivalent dose can obviously reduce the degree of myocardial ischemia and the content of MDA in rats

which indicates a significant protective effect on myocardial ischemia induced by isoproterenol injury in rats.