Objective: To investigate anti-inflammatory and analgesic effects of Lidan Zhitong capsule and its mechanism. Method: The experimental animals were randomly divided into five groups

normal saline group

low dose (mice 0.36 g·kg-1

rats 0.18 g·kg-1) group of Lidan Zhitong capsule

middle dose (mice 0.72 g·kg-1

rats 0.36 g·kg-1) group of Lidan Zhitong capsule

high dose (mice 1.44 g·kg-1

rats 0.72 g·kg-1) group of Lidan Zhitong capsule and aspirin group (mice 0.20 g·kg-1

rats 0.10 g·kg-1). The anti-inflammatory effect was evaluated by dimethylbenzene-caused ear swelling

acetic acid induced celiac capillary permeability in mice and carrageenin induced paw edema in rats. The hotplate test and the acetic acid writhing in mice were used to study the analgesic action. The anti-inflammatory mechanism was evaluated by measuring the contents of intereukin-1(IL-1)

tumor necrosis factor-α(TNF-α)

prostaglandin E2(PGE2) and malon dialdehyde(MDA) in the inflammatory tissue. Result: The middle and high doses of Lidan Zhitong capsule could significantly inhibit the mice ear swelling and rats paw edema(P<0.05

P<0.01)

decrease celiac capillary permeability in mice(P<0.05

P<0.01). The middle and high doses of Lidan Zhitong capsule not only could remarkably improve the pain threshold of hot-plate test(P<0.05

P<0.01)

but also obviously decrease writhing times injected with acetic acid in mice(P<0.05

P<0.01). Lidan Zhitong capsule could also decrease the contents of interleukin-1(IL-1)

tumor necrosis factor-α(TNF-α)

prostagland in E2(PGE2) and malondialdehyde(MDA) in the inflammatory tissue. Conclusion: Lidan Zhitong capsule has remarkable anti-inflammatory and analgesic effects

which may be related to the inhibition of IL-1

TNF-α

PGE2 and MDA.