Objective: To evaluate the efficacy and safety of Pediatric Huanglong granule treating of attention deficit hyperactivity disorder (ADHD)

which belongs to hyperactivity of yang due to yin deficiency in traditional Chinese medicine(TCM). Method: Adopt a randomized

double blind

double modeling

parallel controlled with Jing Ling oral liquid as positive control medicine

multicenter clinical trial design

for a total observation completely accords with the inclusion criteria of children with ADHD belongs to hyperactivity of yang due to yin deficiency in TCM syndrome differentiation 299 cases

including test group 224 cases

control group 75 cases.Test group take Pediatric Huanglong granule according to the method of children aged 6 to 9 years take a bag once

10 to 14 years take two bags once

two times daily

while taking the simulation agent of Jingling oral liquid ; control group take Jingling oral liquid according to the method of children aged 6 to 9 years take one once

10 to 14 years take two once

two times daily

while taking the simulation agent of pediatric Huanglong granule

for 6 weeks. Compare the SNAP - 4 rating scale

conner scale hyperactivity index and TCM syndrome scoring before into the groups and after taking the drug 3 weeks and 6 weeks. Result: Curative effect of the disease:the control effective rate of the test group was 52.68%

the total effective rate was 83.48%; the control effective rate of the control group was 37.34%

the total effective rate was 66.67%. Curative effect of TCM syndromes:the control effective rate of test group was 54.91%

the total effective rate was 87.95%; the control effective rate of control group was 38.67%

the total effective rate was 74.67%.The diseases and TCM syndromes curative effect difference of two groups has statistical significance (P<0.01)

the test group were better than the control group.The primary therapeutic effect index of two groups:SNAP-4 rating scale

conner scale hyperactivity index were tested by t-test after 6 weeks of treatment. The result showed that the difference of two groups was statistical significance (P<0.05). The t-test result of TCM syndrome score after 6 weeks of treatment showed that there were statistical significance between the two groups (P<0.01)

the test group were better than the control group. Patient compliance of two groups were both well

the difference was not statistically significant. Conclusion: Pediatric Huanglong granule has the efficacy of nourishing yin for suppressing hyperactive yang and calming the nerves. It uses for treating ADHD

which belongs to hyperactivity of yang due to yin deficiency in TCM

as it can significantly improve TCM syndrome such as hyperactivity restlessness

rhembasmus

loquacity

quick-tempered

night sweating

mouth and throat feeling dry

hand and foot and heart being prone to heat

insomnia and dreamful sleep

and so on. It has good clinical efficacy and safety

and its clinical curative effect is better than the positive control medicine Jingling oral liquid.