Lontophoresis of Chinese Medicine Combined with Sodium Hyaluronate Injected into Articular Cavity in the Treatment of Early Stage Knee Osteoarthritis

LEI Shou-bin; WANG Gang; ZHANG Bin; LI Chun-gen; DING Pei-dong

doi:10.11653/syfj2014020188

您当前的位置：

首页 >

文章列表页 >

Lontophoresis of Chinese Medicine Combined with Sodium Hyaluronate Injected into Articular Cavity in the Treatment of Early Stage Knee Osteoarthritis

更新时间：2024-01-04

- Lontophoresis of Chinese Medicine Combined with Sodium Hyaluronate Injected into Articular Cavity in the Treatment of Early Stage Knee Osteoarthritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 2, Pages: 188-191(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2014020188
  CLC：
- Published：2014
- 稿件说明：
移动端阅览
LEI Shou-bin, WANG Gang, ZHANG Bin, et al. Lontophoresis of Chinese Medicine Combined with Sodium Hyaluronate Injected into Articular Cavity in the Treatment of Early Stage Knee Osteoarthritis[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(2): 188-191.
DOI：

LEI Shou-bin, WANG Gang, ZHANG Bin, et al. Lontophoresis of Chinese Medicine Combined with Sodium Hyaluronate Injected into Articular Cavity in the Treatment of Early Stage Knee Osteoarthritis[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(2): 188-191. DOI： 10.11653/syfj2014020188.

摘要

目的：探讨通络止痛散中药离子导入联合玻璃酸钠膝关节腔注射治疗早中期膝骨性关节炎（KOA）的临床疗效及作用机制。方法：将98例KOA患者随机按数字法分为观察组和对照组各49例。对照组采用玻璃酸钠20 mg，关节腔内注射，1次/1周，共5周。观察组在对照组治疗的基础上加用通络止痛散中药离子导入，2次/d，连续5周。采用“西安大略和麦克马斯特大学骨关节炎指数”（WOMAC 评分）观察患者症状、体征，检测治疗前后关节液膝关节滑液透明质酸（HA）、肿瘤坏死因子-α（TNF-α）及白细胞介素-1β （IL-1β）水平。结果：观察组总有效率97.96%，优于对照组的81.63%（P<0.01）；观察组WOMAC疼痛、僵硬和日常生活受限各维度评分及总分均低于对照组（P<0.01）；观察组膝关节肿胀和压痛评分低于对照组（P<0.01）；观察组关节液中HA水平高于对照组，TNF-α和IL-1β水平低于对照组（P<0.01）。结论：采用通络止痛散中药离子导入联合玻璃酸钠膝关节腔注射治疗KOA临床疗效显著，其作用机制可能增加关节液中HA浓度，降低关节滑液中TNF-α和IL-1β水平有关。

Abstract

Objective: To observe the clinical effect and mechanism of iontophoresis of Tongluo Zhitong powder articular cavity injection of sodium hyaluronate on the early and medial stages of the knee osteoarthritis. Method: Ninty-eight patients were randomly divided into observation group( n=49) and control group (n=49). Control group were treated with articular cavity injection of sodium hyaluronate

20 mg each time

1 time each week

for 5 weeks. Observation group were treated with iontophoresis of Tongluo Zhitong powder on the basis of control group

2 times each day

for 5 weeks. The symptoms and signs of patients were tested by the Western Ontario and McMaster Universities (WOMAC) scores. The level of hyaluronic aci (HA)

tumor necrosis factor-α (TNF-α) and interleukin-1β(IL-1β) of knee joint synovia in pretherapy and post-treatment were detected. Result: The total effective rate of observation group (97.96%) was superior to control group (81.63%)(P<0.01). The scores of WOMAC which including pain

stiffness

swell and tenderness of observation group were lower than control group (P<0.01). The level of HA in observation group was higher than control group and the level of TNF-α and IL-1β in observation group was lower than control group (P<0.01). Conclusion: The clinical curative effect of iontophoresis of Tongluo Zhitong powder combining with articular cavity injection of sodium hyaluronate on KOA is significant. The mechanism of action may be related with increasing the concentration of HA and decreasing the level of TNF-α and IL-1β.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Analysis on Bogu Huoxue Decoction Combined with Glucosamine Hydrochloride Tablets in Treating 48 Cases with Knee Osteoarthritis

Clinical Analysis of Oral and Fumigating-washing Administration of Bushen Shujin Decoction in Treating 58 Patients with Early Metaphase Knee Osteoarthritis

Xianfang Huoming Decoction Jiawei Iontophoresis Analysis Combined with Clinical of Arthroscopic Debridement for Osteoarthritis of Knee

Preventive and Treatment Effect of Danggui Buxuetang and Liuwei Dihuang Tang on Early Hypertensive Renal Damage

Effect of Xuanfei Pingchuan Capsules on Rat COPD Model

Related Author

LIU Hong-bo

JING Chun-ying

HAN Ping

LIU Xiao-ya

WANG Shang-zeng

ZENG Jiao-fei

LI Mei-zhen

LI Min

Related Institution

Shaanxi University of Chinese Medicine

Affiliated Hospital of Shaanxi University of Chinese Medicine

Haikou Traditional Chinese Medicine Hospital

Quality Control Office,Armed Police Corps Hospital of Henan

Fraditional Chinese Medicine Hospital of Zhongmu County,Zhongmu

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰