Protective Effects of Huihui Gansong Yin on Early Stage of Diabetic Nephropathy

YUAN Ling; NAN Yi; XU Jun; WU You-xi; HUANG Xiu-lan

doi:10.11653/syfj2014030109

您当前的位置：

首页 >

文章列表页 >

Protective Effects of Huihui Gansong Yin on Early Stage of Diabetic Nephropathy

更新时间：2024-01-04

- Protective Effects of Huihui Gansong Yin on Early Stage of Diabetic Nephropathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 3, Pages: 109-113(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2014030109
  CLC：
- Published：2014
- 稿件说明：
移动端阅览
YUAN Ling, NAN Yi, XU Jun, et al. Protective Effects of Huihui Gansong Yin on Early Stage of Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(3): 109-113.
DOI：

YUAN Ling, NAN Yi, XU Jun, et al. Protective Effects of Huihui Gansong Yin on Early Stage of Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(3): 109-113. DOI： 10.11653/syfj2014030109.

摘要

目的：明确回回甘松饮（Huihui Gansong Yin，HGY）对糖尿病肾病大鼠肾脏的保护作用。方法：采用高脂饲料联合链脲佐菌素诱导大鼠实验性糖尿病肾病模型，设正常对照组、模型组、格列喹酮组（10 mg·kg-1）和HGY组（5，10 g·kg-1）。比较给药干预后各组大鼠血清胆固醇（CHO）、甘油三酯（TG）及高、低密度脂蛋白（HDL，LDL）含量；采用酶联免疫吸附方法，检测大鼠糖化血红蛋白A1c（GHbA1c）及尿微量白蛋白（MAU）；分别采用HE染色及PASM染色，光镜下观察肾脏组织的病理变化。结果：与正常对照组比较，模型组大鼠的CHO，TG，LDL，GHbA1c，MAU水平显著上升（P < 0.01），HDL水平显著下降（P < 0.01）。格列喹酮组和HGY组大鼠血脂水平较模型组明显改善（P < 0.01或P < 0.05），GHbA1c及MAU水平均明显低于模型组（P < 0.01），且在降低MAU方面HGY优于格列喹酮（P < 0.01），肾脏病理变化较模型组明显减轻。结论： HGY可改善早期DN大鼠血脂、降低GHbA1c及MAU水平，减轻肾脏病理改变，对早期DN大鼠的肾脏具有一定的保护作用。

Abstract

Objective: To investigate the effects of Huihui Gansong Yin (HGY) on the early stage of diabetic nephropathy. Method: The model of diabetic nephropathy was developed by high-fat diet combined with streptozocin injections. Rats were divided into normal group

model group

glurenorm treatment group(10 mg·kg-1) and HGY treatment group(5

10 g·kg-1).The serum cholesterol(CHO)

triglyceride(TG)

high density lipoproteins(HDL) and low density lipoprotein(LDL) were observed. Enzyme linked immunosorbent assay was used to detect GHbA1c and MAU. The kidneys of rats were harvested for hematoxylin and eosin and the periodic acid-sliver dyeing. The renal lesions were observed under light microscope. Result: Compared with the control group

the level of CHO

LDL

GHbA1c and MAU was significantly increased in the model group(P < 0.01)

while the level of HDL was significantly decreased(P < 0.01). Compared with model group

the levels of blood lipids on the HGY treatment group and glurenorm treatment group were better(P < 0.01 or P < 0.05)

the levels of GHbA1c and MAU were lower(P < 0.01)

meanwhile the HGY treatment group was superior to the glurenorm treatment group on the reduction of MAU. The renal lesions of the HGY and glurenorm treatment groups were lightened than the model group

meanwhile the HGY treatment group was superior to the glurenorm treatment group. Conclusion: HGY may be used to ameliorate blood lipids

decrease the level of GHbA1c and MAU

lessen the pathological of diabetic nephropathy. HGY has protective effects on the early stage of diabetic nephropathy.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mechanism of HIF-1α in Diabetic Nephropathy and Improvement Effect of Traditional Chinese Medicine： A Review

Randomized Controlled Study of Baoshen Prescription in Treating Stage Ⅳ Diabetic Nephropathy in Patients with Syndromes of Qi-Yin Deficiency and Kidney Collateral Stasis and Obstruction

Mechanism of Action of Coptidis Rhizoma and Ophiopogonis Radix in Delaying Diabetic Nephropathy Based on EGFR/PI3K/Akt Signaling Pathway

Research Progress on Traditional Chinese Medicine Interventions Targeting NF-κB Signaling Pathway to Improve Diabetic Nephropathy

Mechanism of Dahuang Tangluo Pills in Improving Renal Inflammatory Injury in Diabetic Kidkdey Disease by Regulating AGEs/RAGE/IKK/NF-κB Pathway

Related Author

XIE Jiarun

LIN Haoyu

CHEN Xi

SUN Jia

WANG Ming

QIU Yiting

HONG Shuangshuang

LIU Zhiqiu

Related Institution

School of Traditional Chinese Medicine，Southern Medical University

Zhujiang Hospital of Southern Medical University

Beijing Hospital of Traditional Chinese Medicine（TCM） Affiliated to Capital Medical University

ZHANG Binghou Studio of National Famous TCM Inheritance

Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao，Henan University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰