Objective: To compare effects of superfine and common powder of Gastrodia elata on the neuroethology

oxidative stress and inflammatory responses in rats with Parkinson's disease (PD). Method: The rat PD model was established by injection of 6-hydroxydopamine (6-OHDA) into the substantia nigra of right side brain. The mice were divided into the normal group

model group

G.elata common powder of low

medium and high dose groups (0.45

0.9

1.8 g·kg-1)

and superfine powder of low

medium and high dose groups (0.45

0.9

1.8 g·kg-1). The changes of neuroethology

oxidative stress and inflammatory responses in PD rats after treatment with superfine and common powder of G. elata were observed. Result: The rats in PD model group after treatment with superfine and common powder of G.elata appeared different levels of improvement of neuroethology. After treatment

superfine and common powder of G. elata could decrease the levels of malondialdehyde (MDA)

nitric oxide (NO) and tumor necrosis factor-α (TNF-α)

increase the content of glutathione (GSH)

and enhance the activity of glutathione-peroxidase (GSH-Px) and superoxide dismutase (SOD) different levels. Conclusion: Both the superfine and common powder of G. elata has the improvement effect on the neuroethology

oxidative stress and inflammatory responses in rats with PD. Furthermore

the superfine powder is more effective than the common powder in pharmacological action

which provide experimental references for the clinical study of superfine powder of G. elata.