Objective: To discuss the clinical efficacy of Suhuang Zhike capsule on acute exacerbation of chronic bronchitis and the effect on inflammatory factor. Method: One hundred and twenry patients were randomly divided into observation group (n=60) and control group (n=60). Control group was given amoxil capsule

0.5 g each time

3 time each day

and ambroxol hydrochloride tablet

30 mg each time

2 time each day

which were taken after meal. Suhuang Zhike capsule was added to observation group on the basis of control group

3 capsules each time

3 times each day. The two groups were treated for 10 days. The cardinal symptoms such as cough and symptom scores were recorded. The time when cough

cough up phlegm

wheeze and pulmonary rale disappeared or turned to be mild was recoreded. interleukin-6 (IL-6)

interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were tested. Result: The total effective rate of observation group (100%) were superior to control group (83.35%) (P<0.01);the symptom scores and the cardinal symptom such as cough

cough up phlegm

wheeze and pulmonary rale of both groups were descended (P<0.01)

and the symptom scores and the cardinal symptom except fever of observation group were lower than control group (P<0.01);the time when cough

cough up phlegm

wheeze and pulmonary rale disappeared or turned to be mild of observation group were less than control group (P<0.01);the level of IL-6

IL-8

TNF-α of both groups were descended than before (P<0.01)

and the level of IL-6

IL-8

TNF-α of observation group were lower than control group (P<0.01). Conclusion: Suhuang Zhike capsule can rapidly relieve the cardinal symptoms of patients with acute exacerbation of chronic bronchitis

improve the clinical symptoms

enhance clinical effects. The mechanism maybe relate to the reduction of the level of IL-6

IL-8

TNF-α in serum and the alleviation of inflammatory damage to air passage.