42 Cases of Stage 3 Chronic Kidney Disease in Treatment of Warming Kidney and Strengthening the Spleen Prescription Therapy

YU Jing-da; YU Jing-ru; DONG Hong

doi:10.11653/syfj2014030194

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42 Cases of Stage 3 Chronic Kidney Disease in Treatment of Warming Kidney and Strengthening the Spleen Prescription Therapy

更新时间：2024-01-04

- 42 Cases of Stage 3 Chronic Kidney Disease in Treatment of Warming Kidney and Strengthening the Spleen Prescription Therapy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 3, Pages: 194-197(2014)
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- DOI：10.11653/syfj2014030194
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- Published：2014
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YU Jing-da, YU Jing-ru, DONG Hong. 42 Cases of Stage 3 Chronic Kidney Disease in Treatment of Warming Kidney and Strengthening the Spleen Prescription Therapy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(3): 194-197.
DOI：

YU Jing-da, YU Jing-ru, DONG Hong. 42 Cases of Stage 3 Chronic Kidney Disease in Treatment of Warming Kidney and Strengthening the Spleen Prescription Therapy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(3): 194-197. DOI： 10.11653/syfj2014030194.

摘要

目的：观察温肾健脾化浊方内服及灌肠法辨证治疗慢性肾脏病3期（CKD3）的临床疗效。方法：将84例CKD3患者随机分为对照组和试验组各42例。两组均采用生活干预，对症处理。观察组在对照组基础上应用温肾健脾化浊方治疗，包括中药内服及在兼证明显时候采用给予化浊方灌肠。疗程均为4个月。记录尿素氮（BUN）、血肌酐（Scr）、肾小球滤过率（eGFR）、尿酸（UA）、24 h尿蛋白定量（Upr）、血清白蛋白（Alb）、甘油三酯（TG）、总胆固醇（TC）、红细胞计数（RBC）、血红蛋白（Hb）的变化情况；记录主要症状、体征评分。结果：观察组疾病疗效总有效率为71.4%，优于对照组的47.6%（P<0.05）；观察组中医证候疗效总有效率为78.6%，优于对照组的57.1%（P<0.05）；观察组Scr较治疗前下降，并低于对照组（P<0.01）；对照组Upr继续上升，观察组Upr下降，治疗后观察组低于对照组（P<0.01）；观察组UA下降，并低于对照组（P<0.01）；对照组eGFR继续下降，治疗后观察组eGFR高于对照组（P<0.05）；观察组TG和TC均较治疗前下降，并低于对照组（P<0.05）。结论：温肾健脾化浊方治疗4个月后改善了CKD3期患者的肾功能，减轻了临床症状，延缓了CKD3期的进展，值得临床使用。

Abstract

Objective: Observation of warming the kidney and strengthening the spleen Huazhuo oral and Enema of dialectical therapy for stage 3 chronic kidney disease (CKD3) clinical curative effect. Method: Eighty-four cases of CKD3 were randomly divided into control group and study group

each of 42 cases. Two groups were treated with lifestyle intervention

symptomatic treatment. Observation group added the application of warming the kidney and strengthening the spleen Huazhuo prescription

including traditional Chinese medicine(TCM) and syndrome was given Huazhuo prescription enema. Treated for 4 months. Record of blood urea nitrogen (BUN)

serum creatinine (Scr)

glomerular filtration rate (GFR)

uric acid (UA)

24 h urinary protein (Upr)

serum albumin (Alb)

triglyceride (TG)

total cholesterol (TC)

red blood cell count (RBC)

hemoglobin (Hb) changes the main symptoms

physical signs score record. Result: The curative effect to total efficiency in study group was 71.4%

more than that of control group 47.6% (P<0.05); the curative effect of TCM syndrome group total effective rate in study group was 78.6%

more than 57.1% of control group (P<0.05);Scr in study group was decreased compared with that before treatment

and lower than that of the control group (P<0.01);control group Upr continued to rise

the study group Upr decreased after treatment

the study group than in the control group (P<0.01);study group UA decreased

and lower than that of the control group (P<0.01);control group eGFR continued to decline

after the treatment were observed in group eGFR than that in the control group (P<0.05);the observation group TG and TC were decreased than that before treatment

and lower than that of the control group (P<0.05). Conclusion: The treatment of warming the kidney and strengthening the spleen Huazhuo prescription after 4 months improved renal function in CKD3 patients

alleviate the clinical symptoms

delay the progress of CKD3 phase

which is worthy of clinical use.

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