Optimization of Processing Technology for Coptidis Rhizoma Steamed with Rice Wine Based on Improvement of Insulin Resistance Activity and Contents of Effective Ingredients

FAN Gang; ZHENG Hai-jie; LAI Xian-rong; MENG Xian-li; ZHANG Yi

doi:10.11653/syfj2014040005

您当前的位置：

首页 >

文章列表页 >

Optimization of Processing Technology for Coptidis Rhizoma Steamed with Rice Wine Based on Improvement of Insulin Resistance Activity and Contents of Effective Ingredients

更新时间：2024-01-04

- Optimization of Processing Technology for Coptidis Rhizoma Steamed with Rice Wine Based on Improvement of Insulin Resistance Activity and Contents of Effective Ingredients
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 4, Pages: 5-8(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2014040005
  CLC：
- Published：2014
- 稿件说明：
移动端阅览
FAN Gang, ZHENG Hai-jie, LAI Xian-rong, et al. Optimization of Processing Technology for Coptidis Rhizoma Steamed with Rice Wine Based on Improvement of Insulin Resistance Activity and Contents of Effective Ingredients[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 5-8.
DOI：

FAN Gang, ZHENG Hai-jie, LAI Xian-rong, et al. Optimization of Processing Technology for Coptidis Rhizoma Steamed with Rice Wine Based on Improvement of Insulin Resistance Activity and Contents of Effective Ingredients[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 5-8. DOI： 10.11653/syfj2014040005.

摘要

目的：优化酒蒸黄连的炮制工艺。方法：以3T3-L1前脂肪细胞胰岛素抵抗模型的葡萄糖利用变化率及3种生物碱（盐酸非洲防己碱、盐酸表小檗碱和盐酸小檗碱）总量为指标，采用均匀设计考察黄酒用量、闷润时间、蒸制时间对酒蒸黄连炮制工艺的影响。结果：酒蒸黄连能显著或部分降低培养液中葡萄糖水平。最佳炮制工艺为黄酒用量20%，闷润时间2 h，蒸制时间8 h；葡萄糖平均利用变化率33.076%，与回归模型预测值的相对误差2.63%；3种生物碱总量平均值8.167%，与回归模型预测值的相对误差1.15%。结论：酒蒸黄连具有改善胰岛素抵抗的活性，优化的酒蒸黄连炮制工艺稳定可行。

Abstract

Objective: To optimize processing technology of Coptidis Rhizoma steamed with rice wine. Method: Taking glucose utilization variation rate of insulin resistance(IR) model of 3T3-L1 adipocyte and total contents of active ingredients(columbamine hydrochloride

epiberberine hydrochloride and berberine hydrochloride) as indexes

uniform design test was adopted to optimize processing technology with rice wine consumption

moistening time and steaming time as factors. Result: Coptidis Rhizoma steamed with rice wine could significantly reduce level of glucose in the culture medium.The best processing technology was as follows:rice wine consumption 20%

moistened 2 h and steamed 8 h;Average glucose utilization variation rate was 33.076%

whose relative error was 2.63% with the predicted value of regression model;Average total contents of three kinds of alkaloids was 8.167% with relative error was 1.15% by comparing with the predicted value. Conclusion: Coptidis Rhizoma steamed with rice wine had a role in improvement of IR;This optimized processing technology was stable and feasible.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Process Optimization and Health Risk Assessment of Calcined Haematitum Based on QbD Concept

Mechanism of Qingrun Prescription-containing Serum Improving Insulin Resistance in HepG2 Cells via Branched-chain α-keto Acid Dehydrogenase Regulation of Branched-chain Amino Acids （BCAAs）/mTOR Pathway

Processing History and Modern Research of Jianghuanglian： A Review

Role of Macrophage Activation and Polarization in Diabetes Mellitus and Its Related Complications and Traditional Chinese Medicine Intervention

Quality Evaluation of Lycii Cortex and Roasted Lycii Cortex Based on Fingerprint and Content Determination

Related Author

YANG Yue

ZHOU Jingwei

ZOU Jialiang

MEI Guorong

SHI Yifan

ZHONG Lei

WANG Jiaojiao

GAN Xuelian

Related Institution

State Key Laboratory of Southwestern Chinese Medicine Resources，School of Pharmacy， Chengdu University of Traditional Chinese Medicine

Sichuan Neo-green Pharmaceutical Technology Development Co. Ltd.，Pengzhou

Guang'anmen Hospital，China Academy of Chinese Medicine Sciences

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine（TCM）

Shunyi Hospital，Beijing TCM Hospital

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰