Optimization of Extraction Technology for Yixin Tongmai Mixtures by Orthogonal Test

LI Yuan-yuan; SONG Ying; FANG Fang; SHENG Rong

doi:10.11653/syfj2014040032

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Optimization of Extraction Technology for Yixin Tongmai Mixtures by Orthogonal Test

更新时间：2024-01-04

- Optimization of Extraction Technology for Yixin Tongmai Mixtures by Orthogonal Test
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 4, Pages: 32-34(2014)
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- DOI：10.11653/syfj2014040032
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- Published：2014
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LI Yuan-yuan, SONG Ying, FANG Fang, et al. Optimization of Extraction Technology for Yixin Tongmai Mixtures by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 32-34.
DOI：

LI Yuan-yuan, SONG Ying, FANG Fang, et al. Optimization of Extraction Technology for Yixin Tongmai Mixtures by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 32-34. DOI： 10.11653/syfj2014040032.

摘要

目的：优选益心通脉合剂的水提工艺。方法：以丹参素钠、毛蕊异黄酮葡萄糖苷含量和干膏收率的综合评分为指标，通过L9（34）正交试验考察加水量、煎煮时间和煎煮次数对益心通脉合剂水提工艺的影响。采用HPLC测定丹参素钠、毛蕊异黄酮葡萄糖苷含量，检测波长分别为280，260 nm。结果：各因素对水提取工艺的影响顺序为提取次数 >加水量 >煎煮时间，最佳水提工艺为加15倍量水煎煮3次，每次0.5 h；丹参素钠和毛蕊异黄酮葡萄糖苷平均提取量分别为4.928，0.399 5 mg·g-1。结论：优选的提取工艺稳定可行，适用于益心通脉合剂的规范化生产。

Abstract

Objective: To optimize water extraction process of Yixin Tongmai mixtures. Method: With contents of salvianic acid A sodium and calycosin-7-glucoside

yield of dry extract as indexes

L9(34) orthogonal test was adopted to investigate effects of the amount of water

decocting time and times on extraction technology.HPLC was adopted to determine contents of salvianic acid A sodium and calycosin-7-glucoside with detection wavelength of 280 and 260 nm

respectively. Result: Effects of each factors on water extraction technology was in order of decocting times >the amount of water >extracting time

optimal extraction conditions were as follows:decocted 3 times with 15-fold water

0.5 h each time;Under these conditions

average extracting amounts of salvianic acid A sodium and calycosin-7-glucoside were 4.928 and 0.399 5 mg·g-1

respectively. Conclusion: Optimized extraction process was stable and feasible

which was suitable for standardization production of Yixin Tongmai mixtures.

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