-Glucosidase Inhibitory Activity of  Koehne

ZHANG Wei; CHANG Mei-fang; JIN Jing-yi; SHEN Qian; WANG Jun-jie; KANG Wen-yi

doi:10.11653/syfj2014040084

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-Glucosidase Inhibitory Activity of Koehne

更新时间：2024-01-04

- -Glucosidase Inhibitory Activity of Koehne
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 4, Pages: 84-86(2014)
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- DOI：10.11653/syfj2014040084
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- Published：2014
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ZHANG Wei, CHANG Mei-fang, JIN Jing-yi, et al. -Glucosidase Inhibitory Activity of Koehne[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 84-86.
DOI：

ZHANG Wei, CHANG Mei-fang, JIN Jing-yi, et al. -Glucosidase Inhibitory Activity of Koehne[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 84-86. DOI： 10.11653/syfj2014040084.

摘要

目的：对垂丝海棠花和叶α-葡萄糖苷酶抑制活性进行研究。方法：利用体外α-葡萄糖苷酶抑制模型，以阿卡波糖为阳性对照对α-葡萄糖苷酶抑制活性评价。结果：垂丝海棠花和叶的不同提取部位均具有一定的α-葡萄糖苷酶抑制活性，垂丝海棠叶70%乙醇部位（IC50=69.68 mg·L-1）的α-葡萄糖苷酶的抑制活性最好，远高于阳性对照阿卡波糖（IC50=1 213.38 mg·L-1）。垂丝海棠叶中70%乙醇部位、石油醚部位和乙酸乙酯部位活性均高于垂丝海棠花中相应部位，而叶中正丁醇部位略低于花的正丁醇部位，且都高于阳性对照阿卡波糖。此外，各部位的抑制活性均与质量浓度呈现相关性，具有一定的浓度依赖性。结论：垂丝海棠花和叶不同提取部位均具有一定的α-葡萄糖苷酶抑制活性，但不同提取部位其抑制活性有差别。

Abstract

Objective: To evaluate the α-glucosidase inhibitory activity of the flowers and leaves of Malus halliana Koehne. Method: By used α-glucosidase inhibitory model in vitro and with acarbose as positive control

the α-glucosidase inhibitory activity of the flowers and leaves of M. halliana were evaluated. Result: Different extracts from the flowers and leaves of M. halliana all had inhibitory activity of α-glucosidase

among which leaves of M. halliana 70% ethanol extract (IC50=69.68 mg·L-1) had the highest inhibitory activity of α-glucosidase

it was far higher than that of the positive control acarbose (IC50=1 213.38 mg·L-1). 70% Ethanol extract

petroleum ether extract and ethyl acetate extract of leaves of M. halliana were higher than that of corresponding extract of flowers of M. halliana

while n-butanol extract of leaves was lower than that of n-butanol extract of flowers

and they were all higher than that of acarbose. In addition

the concentration of all extracts showed positive correlation with inhibitory activity

and also showed a certain degree of concentration dependence. Conclusion: Different extracts from the flowers and leaves of M. halliana all had inhibitory activity of α-glucosidase

but different extracts of the inhibition rate had certain difference.

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