Pharmacokinetics of Veratric Acid in Rats

AN Yan-nan; WANG Ru-feng; WU Xiu-wen; LIU Li-jia; PENG Yu-shuai; LI Cang-hai; ZHOU Chang-zheng

doi:10.11653/syfj2014040091

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Pharmacokinetics of Veratric Acid in Rats

更新时间：2024-01-04

- Pharmacokinetics of Veratric Acid in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 4, Pages: 91-93(2014)
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- DOI：10.11653/syfj2014040091
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- Published：2014
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AN Yan-nan, WANG Ru-feng, WU Xiu-wen, et al. Pharmacokinetics of Veratric Acid in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 91-93.
DOI：

AN Yan-nan, WANG Ru-feng, WU Xiu-wen, et al. Pharmacokinetics of Veratric Acid in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 91-93. DOI： 10.11653/syfj2014040091.

摘要

目的：考察藜芦酸在大鼠体内的药代动力学。方法：大鼠口服灌胃给予藜芦酸，在不同时间点采集血样，选择3，4-二羟基苯甲酸甲酯为内标，采用HPLC测定血药浓度，流动相乙腈（A）-1%乙酸（B）梯度洗脱（0~11 min，5%~57%A；11~13 min，57%~5%A），检测波长256 nm，绘制血药浓度-时间曲线，通过Kinetica 4.4软件计算药代动力学参数。结果：灌胃给药后藜芦酸在大鼠体内的达峰时间分别为（45.00±10.00），（31.00±8.22）min，存在二次达峰现象；高、低剂量组的Cmax分别为（176.85±28.89），（68.14±12.58）mg·L-1，t1/2分别为（87.74±20.74），（227.18±93.78）min，AUC0-∞分别为（50 363.50±11 667.7），（18 830.32±4 354.35）min·mg·L-1，MRT0-∞分别为（201.39±16.72），（227.40±21.37）min。结论：藜芦酸口服吸收较快，消除较慢，体内作用时间较长。

Abstract

Objective: To study pharmacokinetics of veratric acid in rats. Method: Veratric acid was administrate to rats by oral gavage

blood samples were collected at various time points

HPLC was adopted to determine the content of veratric acid in blood samples by taking 3

4-dihydroxybenzoic acid methyl ester as an internal standard

mobile phase of acetonitrile(A)-1% acetic acid(B) (0-11 min

5%-57%A;11-13 min

57%-5%A)

detection wavelength was set at 256 nm

plasma concentration-time curve was drawn

pharmacokinetic parameters were calculated by Kinetica 4.4 software. Result: After oral gavage administration

veratric acid existed secondary peak phenmenon in rats

Tmax were (45.00±10.00) and (31.00±8.22) min

respectively;Cmax of high and low dose groups were (176.85±28.89) and (68.14±12.58) mg·L-1

t1/2 were (87.74±20.74) and (227.18±93.78) min

AUC0-∞ were (50 363.50±11 667.7) and (18 830.32±4 354.35) min·mg·L-1

MRT0-∞ were (201.39±16.72) and (227.40±21.37) min

respectively. Conclusion: Veratric acid had a long in vivo acting time due to its quick absorption and slow elimination.

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