WANG Meng, REN Xiao-liang, OUYANG Hui-zi, et al. Study on Tissue Distribution of Stilbene Glycoside (THSG) and its -cyclodextrin Inclusion[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 98-102.
DOI:
WANG Meng, REN Xiao-liang, OUYANG Hui-zi, et al. Study on Tissue Distribution of Stilbene Glycoside (THSG) and its -cyclodextrin Inclusion[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 98-102. DOI: 10.11653/syfj2014040098.
Study on Tissue Distribution of Stilbene Glycoside (THSG) and its -cyclodextrin Inclusion
Objective: The tissue distribution characteristics of stilbene glycoside (THSG) and its β-cyclodextrin inclusion in 8 tissues after oral administration to rats were studied. Method: The samples of 8 different tissues were collected at 15
30
60 min
respectively. The content of THSG was determined by HPLC-UV. Result: The HPLC-UV method established was available for analysis of THSG in tissues and met the requirements of biological sample analysis. There was no significant difference of THSG concentration in the spleen
lung
brain and pancreas between THSG group and β-CD-THSG complex group. However
the concentration of THSG in the tissues materials of heart
kidneys and fat was higher by given β-CD-THSG complex. In addition
tmax of THSG in tissues was delayed by given β-CD-THSG complex
which was observed obviously in heart
liver
spleen and fat tissue. Conclusion: β-CD inclusion only changed the tmax of THSG in the tissues
and will not cause the accumulation in the tissues.
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