Objective: To explore the anti-tumor and immunoregulation effects of Feiliuping on S180 tumor-bearing mice. Method: The ICR mice inoculated subcutaneously with S180 cells were randomly divided into five groups:the negative control group

the positive control group (Zilongjin

2.60 g·kg-1

ig)

high-

moderate-

and low-dose of Feiliuping groups (25.00

12.50

6.25 g·kg-1

ig). Normal mice without S180 were designated as normal group. After corresponding treatments for 10 days

the tumor inhibitory rate

index of thymus and spleen

rate of peritoneal macrophage phagocytizing chicken red blood cell

level of serum hemolysin

spleen lymphocyte transformation

and NK cell killing activity were tested. Result: Feiliuping could obviously inhibit the growth of S180 sarcoma

the tumor inhibitory rates of high-

moderate-

and low-dose groups were 51.88%

32.33%

37.59%

respectively

however

the indexes of thymus and spleen of mice were not changed. Feiliuping significantly improved the killing activity of peritoneal macrophages and NK cells

increased the level of serum hemolysin

promoted lymphocyte transformation on mice of S180 cells-derived tumor. Conclusion: Feiliuping can inhibit the growth of S180 implant tumor and enhance the immune function of the tumor-bearing mice

the tumor growth inhibition and immune capability enhancement of Feiliuping are more effective than Zilongjin.