WANG Gui-hong, PAN Jian-ying, WANG Rui, et al. Mechanism of Liqi Xiaoying Tablet on Goiter of Experimental Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 159-163.
DOI:
WANG Gui-hong, PAN Jian-ying, WANG Rui, et al. Mechanism of Liqi Xiaoying Tablet on Goiter of Experimental Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 159-163. DOI: 10.11653/syfj2014040159.
Mechanism of Liqi Xiaoying Tablet on Goiter of Experimental Rats
Objective: To explore the possible mechanism of Liqi Xiaoying tablet on rat goiter. Method: Sprague Dawley (SD) rats were randomly divided into six groups:normal control group
model group
Liqi Xiaoying tablet low
middle and high dose group
euthyrox group. In addition to the normal control group
the rest of the rats in each group were fed daily propylthiouracil (20 mg·kg-1) to establish the model
Liqi Xiaoying tablet low
middle and high dose group were fed simultaneously 2.4
4.8
9.6 g·kg-1 of Liqi Xiaoying tablet solution
positive drug group was given 7.8 μg·kg-1 of euthyrox. Sixty days later the animals were sacrificed and serum thyroid tissue specimens were collected. Rat thyroid index calculation
serum free triiodothyronine (FT3)
free thyroxine (FT4)
thyroid-stimulating hormone (TSH) levels
thyroid pathological changes were observed
immunofluorescence staining was used to saasy thyroid tissue basic fibroblast growth factor (bFGF)
B cell lymphoma/lewkmia-2(Bcl-2)
transforming growth factor beta (TGF-β) expression changed. Result: Compared with normal group
in model group
serum FT3
FT4 levels increased (P<0.05)
TSH decreased (P<0.05)
significantly enlarged
thyroid (P<0.01)
bFGF
Bcl-2 expression was significantly increased
TGF-β expression was significantly decreased. Compared with model group
Liqi Xiaoying tablet could significantly reduce goiter index (P<0.05)
but change of serum FT3
FT4
TSH levels was not obvious
reduced the pathological changes of the thyroid
bFGF
Bcl-2 expression (P<0.01)
elevated TGF-β expression (P<0.01). Conclusion: Liqi Xiaoying tablet has the role of anti-goiter
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