Role of  in Preventing Acute Mercury Toxicity in Rats

ZHENG Jie; ZHENG Yu-xiang; XIAO Feng-xia; LIN Li; LIN Jing-ran

doi:10.11653/syfj2014040163

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Role of in Preventing Acute Mercury Toxicity in Rats

更新时间：2024-01-04

- Role of in Preventing Acute Mercury Toxicity in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 4, Pages: 163-166(2014)
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- DOI：10.11653/syfj2014040163
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- Published：2014
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ZHENG Jie, ZHENG Yu-xiang, XIAO Feng-xia, et al. Role of in Preventing Acute Mercury Toxicity in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 163-166.
DOI：

ZHENG Jie, ZHENG Yu-xiang, XIAO Feng-xia, et al. Role of in Preventing Acute Mercury Toxicity in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(4): 163-166. DOI： 10.11653/syfj2014040163.

摘要

目的：探讨土茯苓对急性汞中毒大鼠的保护作用。方法：将大鼠随机分为正常对照组、模型组、土茯苓高、中、低剂量组（5，10，20 g·kg-1），模型组及土茯苓高、中、低剂量组sc 2.5 mg·kg-1 HgCl2溶液，连续2 d，造成汞中毒，正常对照组sc生理盐水；土茯苓水煎液低、中、高剂量组末次染毒后开始ig给药，ig体积10 mL·kg-1，2次/d，早晚各1次，持续3 d，观察土茯苓对染汞大鼠血清尿素氮（BUN）、汞、尿蛋白、尿乳酸脱氢酶（LDH）、尿碱性磷酸酶（ALP）活力、尿汞、肾汞、肝汞含量及肾脏病理组织学变化的影响。结果：与正常对照组比较，模型组尿汞、血汞和肝汞、肾皮质汞含量，尿LDH及ALP活力，尿蛋白和血清BUN含量均显著提高（P<0.01），肾脏损伤明显；与模型组对比，土茯苓水煎液高、中剂量组血清BUN、尿蛋白，尿LDH及ALP活力，肾、肝及血汞含量显著降低，尿汞含量显著增加（P<0.01或P<0.05）；肾脏病理组织学观察结果显示，高剂量组土茯苓对汞中毒大鼠肾损伤有较好的修复作用。结论：土茯苓具有能够改善汞中毒大鼠肝肾功能、去除体内汞蓄积的作用，对汞中毒大鼠具有一定的防治作用。

Abstract

Objective: To investigate the role of Smilax glabra in the protective effect of acute mercury poisoning in rats. Method: The rats were divided into five groups:normal control group

model group

high

middle and low dose of S. glabra group.The control group was only given 0.9% saline by subcut aneousinjection andthe other groupswere injected with HgCl2 of 2.5 mg·kg-1 once a day for two days

the high

middle and low dose of S. glabra group were orally given twice a day for three days after the last injection

the influence of S. glabra aqueous extract on the serum blood urea nitrogen(BUN)

lactate dehydrogenase(LDH) and alkaline phosphatase(ALP)

the urinary protein

the levels of mercury in urine

renal cortex and liver and the renal histopathological changeswereobserved. Result: Compared with the blank control group

the serum BUN

the urinary activities of LDH and ALP

the urinary protein

and the levels of mercury in urine

renal cortex and liverfrom the chlorinated mercury groupwere increased significant(P<0.01).Further more

compared with the model group

the serum BUN

the urinary activities of LDH and ALP

the urinary protein

and the levels of mercury in urine

renal cortex and liver from the high or medium S. glabra aqueous extract group were reduced significant(P<0.01 or P<0.05). The results of kidney pathological histology observation showedc that S. glabra had an obviously improvementon the acute mercury poisoningrats. Conclusion: S. glabra can improve the liver and kidney function of mercury poisoning in rats and decrease the accumulation of mercury in vivo

the S.glabra shows definite preventive and therapeutic effect on acute mercury poisoned rats.

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