Correlation Analysis of Physical Properties and Yield Pressure of Traditional Chinese Medicine Powder

CAO Han-han; DU Ruo-fei; YANG Jia-ning; FENG Yi; WANG Song-tao

doi:10.11653/syfj2014050014

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Correlation Analysis of Physical Properties and Yield Pressure of Traditional Chinese Medicine Powder

更新时间：2024-01-04

- Correlation Analysis of Physical Properties and Yield Pressure of Traditional Chinese Medicine Powder
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 5, Pages: 14-17(2014)
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- DOI：10.11653/syfj2014050014
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- Published：2014
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CAO Han-han, DU Ruo-fei, YANG Jia-ning, et al. Correlation Analysis of Physical Properties and Yield Pressure of Traditional Chinese Medicine Powder[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 14-17.
DOI：

CAO Han-han, DU Ruo-fei, YANG Jia-ning, et al. Correlation Analysis of Physical Properties and Yield Pressure of Traditional Chinese Medicine Powder[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 14-17. DOI： 10.11653/syfj2014050014.

摘要

目的：考察中药粉体物理性质与屈服压力的相关性。方法：利用Heckel方程中屈服压力来表征粉体的可压性。采用多元线性回归分析法考察中药粉体的休止角、崩溃角、平板角、含水量、松密度、振实密度、吸湿性、平均粒径等参数与屈服压力的相关关系。结果：模型药物中屈服压力在52.76~261.64 MPa，其中麦冬、金钱草、五倍子提取物的屈服压力较大，回归方程表明休止角、振实密度、吸湿性、平均粒径与屈服压力呈明显的正相关，崩溃角、平板角、含水量、松密度与屈服压力则呈明显的负相关。结论：中药粉体的物理性质是影响其可压性的重要因素，其中休止角、振实密度、吸湿性和平均粒径对可压性的影响较大。

Abstract

Objective: To investigate correlation between physical properties and yield pressure of traditional Chinese medicine powder and to find out main factors affecting compressibility. Method: Compressibility was characterized by yield pressure of Heckel equation.Correlation between physical properties including angle of repose

collapse of angle

flat angle

water content

bulk density

tap density

moisture absorption

average particle size and yield pressure were investigated by multiple regression analysis. Result: Yield pressure of model drugs was in range of 52.76-261.64 MPa

yield pressures of Galla Chinensis extract

Ophiopogonis Radix extract and Lysimachiae Herba extract were greater than other substances.Regression equation showed angle of repose

tap density

moisture absorption and average particle size were positively correlated with yield pressure in measured range

but collapse of angle

flat angle

water content and bulk density were negatively correlated with yield pressure in measured range. Conclusion: Physical properties of traditional Chinese medicine powder had great effect on compressibility

wherein impact of angle of repose

moisture absorption

tap density and average particle size was comparatively great.

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