Objective: To optimize spray drying process of Schisandrae Chinensis Fructus polysaccharides microcapsules and evaluate its quality and in vitro release pattern. Method: With chitosan as a carrier

Schisandrae Chinensis Fructus polysaccharides microcapsules was prepared by spray drying method

orthogonal design was adopted to investigate effects of quality rate of drug-chitosan

the mass fraction of chitosan

inlet velocity and inlet air temperature on preparation technology by taking composite score of yield and drug loading as index

quality of Schisandrae Chinensis Fructus polysaccharides microcapsules was evaluated and investigate its in vitro release characteristics. Result: Optimal preparation process was as follows:drug-chitosan(1 ：3)

the mass fraction of chitosan 2.0%

inlet air temperature 160 ℃

inlet velocity 5 mL·min-1

air flow rate 600 L·h-1;These prepared microcapsules had rounded smooth surface without adhesions

drug loading was 22.71%

yield was 62.04%

encapsulation efficiency was 83.27%

average particle size was 13.47 μm

cumulative release in 1

8 h were 47.86 and 84.19%

in vitro drug release profile could be described by Higuchi equation of Q=29.365t1/2+11.033(r=0.955 7) at 0-8 h. Conclusion: Entrapment efficiency of polysaccharides chitosan microcapsules prepared by spray drying method was high with some burst effects and sustained release performance.