Optimization of Formula of Hyperici Perforati Herba Extract Sustained-release Tablets

SONG Hong-xin; XING Hong-xiang; LI Nan

doi:10.11653/syfj2014050038

您当前的位置：

首页 >

文章列表页 >

Optimization of Formula of Hyperici Perforati Herba Extract Sustained-release Tablets

更新时间：2024-01-04

- Optimization of Formula of Hyperici Perforati Herba Extract Sustained-release Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 5, Pages: 38-41(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2014050038
  CLC：
- Published：2014
- 稿件说明：
移动端阅览
SONG Hong-xin, XING Hong-xiang, LI Nan. Optimization of Formula of Hyperici Perforati Herba Extract Sustained-release Tablets[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 38-41.
DOI：

SONG Hong-xin, XING Hong-xiang, LI Nan. Optimization of Formula of Hyperici Perforati Herba Extract Sustained-release Tablets[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 38-41. DOI： 10.11653/syfj2014050038.

摘要

目的：优选贯叶连翘提取物凝胶骨架缓释片的处方并考察其体外释药机制。方法：以贯叶连翘提取物中金丝桃素在不同时间点的累积释药率为综合评价指标，采用正交试验考察乳糖和MCC质量比、骨架材料及HPMC用量对处方工艺的影响。利用体外释放度试验考察缓释片的释药机制。结果：优选的处方工艺为HPMC K15M用量30%，MCC用量6.4%，乳糖用量12.6%，硬脂酸镁用量1%。贯叶连翘提取物凝胶骨架缓释片在2 h释药率15%~30%，6 h释药率40%~75%，12 h释药率>85%，释药行为符合Ritger-Peppas方程，释药过程为药物扩散和骨架溶蚀的协同作用。结论：优选的处方工艺合理、简单。制备的缓释片体外释药缓慢、平稳，药物释放机制符合释放动力学模型。

Abstract

Objective: To optimize formula of Hyperici Perforati Herba extract sustained-release tablets and evaluate its in vitro release mechanism. Method: With cumulative release rate of hypericin at different time points as comprehensive evaluation index

orthogonal test was adopted to optimize formula of Hyperici Perforati Herba extract sustained-release tablets by taking quality ratio of MCC to lactose

framework materials and the amount of HPMC as factors.Release mechanism of sustained-release tablets was investigated by in vitro release test. Result: Optimized prescription process was as follows:HPMC K15M 30%

MCC 6.4%

lactose 12.6%

magnesium stearate 1%.Drug release of Hyperici Perforati Herba extract sustained-release tablets in 2 h was 15%-30%

it was 40%-75% in 6 h and more than 85% in 12 h.In vitro release behavior was in line with Ritger-Peppas equation

release process was described by synergy of drug diffusion and skeleton corrosion. Conclusion: Optimized prescription process was reasonable and simple.In vitro release of these prepared sustained-release tablets was slow and stable

its release mechanism followed kinetic model of sustained-release tablets.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Preparation and Correlation Analysis in Rabbits of Total Glycosides Sustained-Release Tablets of Sanqing Jiangtang Decoction

Optimum of Gel Sustained-release Matrix Tablets by Orthogonal Design

Study on Influencing Factors on Release of Total Flavones from HPMC Matrix Tablets

Optimization of ultrasonic extraction of hypericin in Hypericum perforatum L. using response surface methodology

Related Author

LV Li-xun

LI Tang-di

ZHAO Lin-lin

ZHAO Li-gang

LIU Gui-hua

XING Jian-guo

XUE Gui-peng

WANG Xin-chun

Related Institution

College of Pharmacy,Henan University of Traditional Chinese Medicine

School of Life Science and Engineering,Southwest Jiaotong University

School of Pharmacy,Shihezi University

Xinjiang Institute of Meteria

The First Affiliated Hospital of Medical College

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰