Stability of Icariside and Factors Affecting the Stability

CHEN Yi-ping; CHEN Shuang-ying; CHEN Wen-cai; LIU Yuan-jun

doi:10.11653/syfj2014050078

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Stability of Icariside and Factors Affecting the Stability

更新时间：2024-01-04

- Stability of Icariside and Factors Affecting the Stability
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 5, Pages: 78-81(2014)
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- DOI：10.11653/syfj2014050078
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- Published：2014
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CHEN Yi-ping, CHEN Shuang-ying, CHEN Wen-cai, et al. Stability of Icariside and Factors Affecting the Stability[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 78-81.
DOI：

CHEN Yi-ping, CHEN Shuang-ying, CHEN Wen-cai, et al. Stability of Icariside and Factors Affecting the Stability[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 78-81. DOI： 10.11653/syfj2014050078.

摘要

目的：分析测定淫羊藿苷在不同条件下的稳定性及其影响因素。方法：采用紫外-可见分光光度法在200~600 nm扫描，测定不同条件下对淫羊藿苷结构的影响。结果：在微酸性、微碱性和中性条件下，淫羊藿苷可保持结构稳定。在pH<2和pH>10 时，结构发生明显变化；淫羊藿苷热稳定性较好，在100 ℃长时间加热其仍可以稳定存在；能与过渡金属离子Cu2+，Fe3+，Al3+形成络合物，对淫羊藿苷的氧化起到了诱导催化作用从而对其结构有明显的影响。结论：紫外-可见光谱法能够初步考察不同条件下对淫羊藿苷稳定性的影响，为淫羊藿苷的提取、制剂和衍生物制备等提供重要信息。

Abstract

Objective: To analyze and determine the stability of icariside and its factors affecting in different conditions. Method: On the basis of ultraviolet-visible spectrum under 200-600 nm region scan

determine the factors affecting the chemical structure of icariside in different conditions. Result: Icariside was stable in water

incruding slightly acidic

basic and neutral conditions.When it existed in aqueous phase under pH<2 or pH>10 conditions

the chemical structure of icariside was changed. Furthermore

its aqueous phase under 100 ℃ for a long time was remain stable. In the processes of extracting and using icariside

metal ion such as Cu2+

Fe3+and Al3+ should be wiped off

as they were able to chelate with icariside

and could induce oxidation as well. Conclusion: Using ultraviolet-visible spectrum can primary observation the factors affecting the stability of icariside in different conditions

and providing important information on its extraction

preparation and derivatives preparation.

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