Study on Antioxidant Activity of Stigmaserol from Yulangsan

HUANG Jian-chun; QING Li-juan; XUAN Fei-fei; LIANG Xing-mei; HUANG Ren-bin

doi:10.11653/syfj2014050154

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Study on Antioxidant Activity of Stigmaserol from Yulangsan

更新时间：2024-01-04

- Study on Antioxidant Activity of Stigmaserol from Yulangsan
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 5, Pages: 154-156(2014)
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- DOI：10.11653/syfj2014050154
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- Published：2014
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HUANG Jian-chun, QING Li-juan, XUAN Fei-fei, et al. Study on Antioxidant Activity of Stigmaserol from Yulangsan [J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 154-156.
DOI：

HUANG Jian-chun, QING Li-juan, XUAN Fei-fei, et al. Study on Antioxidant Activity of Stigmaserol from Yulangsan [J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 154-156. DOI： 10.11653/syfj2014050154.

摘要

目的：研究玉郎伞一种甾醇类化合物豆甾醇（stigmaserol）的体外抗氧化活性。方法：配制含磷酸盐缓冲液（pH 8.3）50 mmol·L-1、连苯三酚0.2 mmol·L-1 的溶液，建立连苯三酚氧自由化产生氧自由基（O2-·）发生体系；配制含邻二氮菲0.75 mmol·L-1，FeSO4 0.75 mmol·L-1、磷酸盐缓冲液（pH 7.3）150 mmol·L-1的溶液，建立由邻二氮菲-Fe2+/H2O2产生羟自由基（·OH）的发生体系，以维生素C（Vit C）为阳性对照，采用紫外-可见分光光度法，测定豆甾醇对O2-·和·OH的清除及抑制作用。结果：高、中浓度豆甾醇对·OH有明显的清除作用，清除率分别为39.3%，9.9%（P<0.01或P<0.05）；对O2-·有明显的清除作用，清除率分别为61.2%，30.4%（P<0.01），且能显著减小O2-·的生成速率，抑制率分别为38.3%，47.8%（P<0.01）。结论：豆甾醇在体外具有较强的抗氧化活性。

Abstract

Objective: To study the antioxidant activity of stigmaserol from Yulangsan in vitro. Method: The superoxide anion free radical (O2-·) and hydroxy free radical (· OH) were prepared through pyrogallol and o-phenanthroline-Fe2+/H2O2 system respectively

the ultraviolet-visible spectrophotometry was used to observe the scavenging and inhibiting effects of stigmaserol on O2-· and ·OH with the vitamin C (Vit C) as positive control. Result: Stigmaserol separated from Yulangsan greatly scavenged O2-· and ·OH (P<0.01 or P<0.05)

and significantly reduced the production rate of O2-· (P<0.01). Conclusion: Stigmaserol has strong antioxidant activity.

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