Study of Shenqi Huafen Pian on Exercise-induced Fatigue in Rats

MIAO Ming-san; JIANG Mei-qiong; ZHANG Xue-xia

doi:10.11653/syfj2014050177

您当前的位置：

首页 >

文章列表页 >

Study of Shenqi Huafen Pian on Exercise-induced Fatigue in Rats

更新时间：2024-01-04

- Study of Shenqi Huafen Pian on Exercise-induced Fatigue in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 5, Pages: 177-179(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2014050177
  CLC：
- Published：2014
- 稿件说明：
移动端阅览
MIAO Ming-san, JIANG Mei-qiong, ZHANG Xue-xia. Study of Shenqi Huafen Pian on Exercise-induced Fatigue in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 177-179.
DOI：

MIAO Ming-san, JIANG Mei-qiong, ZHANG Xue-xia. Study of Shenqi Huafen Pian on Exercise-induced Fatigue in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 177-179. DOI： 10.11653/syfj2014050177.

摘要

目的：探讨参芪花粉片抗疲劳的作用特点。方法：将70 只雄性SD大鼠随机分为空白组、模型组、参芪花粉片高、中、低剂量组（2.5，1.25，0.625 g·kg-1）、硝苯地平片组（0.01 g·kg-1）、刺五加片组（0.25 g·kg-1）。连续 ig 给药 9 d。采用负重游泳实验造大鼠力竭模型。测定体重、肝脏中三磷酸腺苷酶（ATP）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）、肾脏中丙二醛（MDA）、超氧化物歧化酶（SOD）、血乳酸（LD）等指标。结果：与空白组比较，模型组ATP，CAT，GSH-Px，MDA，SOD，血LD等指标显著降低（P<0.01）。高、中剂量参芪花粉片组体重均大于模型组（P<0.01）。与模型组相比，高剂量参芪花粉片组可明显改善肝脏Na+-K+-ATP酶、Mg2+-ATP酶和Ca2+-ATP酶活性（P<0.05），显著提高肝脏GSH-Px活性（928.4±150.1）U·mL-1（P<0.01）和肾脏SOD活性（289.0±4.2）UN·mL-1（P<0.01）；高、中剂量参芪花粉片组均可显著提高肝匀浆CAT活性（399.2±78.1），（372.0±139.9）U·g-1（P<0.01），显著降低肾脏MDA水平（1.93±0.33），（2.18±0.47）nmol·mg-1（P<0.01），明显降低血LD水平（7.84±1.18），（9.69±1.36）mmol·L-1（P<0.05）。结论：参芪花粉片可显著增强大鼠的抗疲劳能力，其作用可能与抗氧化和加速乳酸代谢有关。

Abstract

Objective: To study of Shenqi Huafen Pian on exercise-induced fatigue in rats. Method: Seventy male SD rats were randomly divided into normal control group

model control group

Shenqi Huafen Pian high

medium

low dose groups(2.5

1.25

0.625 g·kg-1)

Nifedipine tablets groups(0.01 g·kg-1)

Ciwujia tablets groups (0.25 g·kg-1).Drugs were administered to mice for 9 days.Except control group

the other 6 groups were conducted exhaustive swimming experiment. The weight

MDA(malonaldehyde) and lactic acid(LD) content

adenosine triphosphatase(ATPase)

catalase(CAT)

Glutathione peroxidase(GSH-Px) and superoxidedismutase(SOD) activity were measured. Result: The weight in Shenqi Huafen Pian high

medium dose groups was increased(P<0.01).In high dose group of Shenqi Huafen Pian

Na+-K+-ATPase activity

Mg2+-ATPase and Ca2+-ATPase activity of liver cells were obviously increased compared with model(P<0.05)

GSH-Px activity in liver was significantly higher than that in model group(P<0.01)

activities of SOD in kidney were significantly higher than that(P<0.01).In high and middle dose group of Shenqi Huafen Pian

CAT activities in liver were significantly higher than that in model group(P<0.01)

MDA content in kidney was lower than that(P<0.01)

blood LD contents were obviously lower than that in model group(P<0.05). Conclusion: Shenqi Huafen Pian showed anti-fatigue effects.The effects could be mediated by increasing the ability of antioxidation and improving lactate metabolism.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Polysaccharides from Root， Stem， Leaf and Fruit of Schisandra chinensis on Exercise Endurance in D-galactose-induced Aging Mice

Changes in Effective Compounds and Anti-fatigue Activity Before and After Compatibility of Ginseng Radix et Rhizoma Rubra and Rhodiolae Crenulate Radix et Rhizoma

Promotive Effect of Jufeng Ⅰ,Ⅱ Oral Liquids on the Sport Activity in Mice

Experimental studies on anti-fatigue of Campou Medicine Qi-Xue-Shuei prescription No1

Determination of Optimum Dosage of Ingredieunts in XingShenFang by Uniform-design Method

Related Author

Jia-hui FANG

Jia-wei LIU

Yu-xin JIANG

Shu JING

Chun-mei WANG

Jing-hui SUN

Cheng-yi ZHANG

Jian-guang CHEN

Related Institution

College of Pharmacy， Beihua University

Affiliated Hospital of Beihua University

Jilin Ginseng Academy，Changchun University of Chinese Medicine

The Third Clinical Medical Hospital of Changchun University of Chinese Medicine

China University of Petroleum

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰