HU Zheng-fang, LI Chu-xi, LIU Yan, et al. Study on General Pharmacology of Nanwuweizi Softcapsule[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 184-187.
DOI:
HU Zheng-fang, LI Chu-xi, LIU Yan, et al. Study on General Pharmacology of Nanwuweizi Softcapsule[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(5): 184-187. DOI: 10.11653/syfj2014050184.
Study on General Pharmacology of Nanwuweizi Softcapsule
Objective: To observe the effects of Nanwuweizi softcapsule on nervous system in mice as well as respiration system and cardiovascular system in dogs. Method: Mice were given oral medicine with different doses (100
200
400 mg·kg-1) of Nanwuweizi softcapsule
and general behavior
spontaneous locomotor test
cooperation movement ability and synergistic effect with pentobarbital-sodium in mice were observed. Anesthetized dog were given Nanwuweizi softcapsule via duodenum with different doses (50
100
200 mg·kg-1) to observe the effect on respiration system and cardiovascular system in dogs. Result: Nanwuweizi softcapsule had no affect on mice's general behavior
rotating bar and balance beam activity
as well as canine respiration system and cardiovascular system
including frequence and depth of respiration
systolic blood pressure(SBP)
diastolic blood pressure(DBP)
mean blood pressure(MBP)
heat rate(HR)
T-wave
P-wave
PR
QRS
QT interval segment of electrocardiogram. It decreased the locomotor activity and had synergistic effect with pentobarbital-sodium in mice with shorter sleep latency and longer sleep lasting time. Conclusion: Nanwuweizi softcapsule had no significant effects on general behavior
cooperation movement ability in mice as well as respiration and cardiovascular system in dogs. Nanwuweizi softcapsule had suppressive effect on spontaneous locomotor test and synergistic effect with pentobarbital-sodium in mice
which was consistent with the hypnagogic activity of Nanwuweizi softcapsule.
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