Study on Transdermal Permeability of Notoginsenoside R, Ginsenoside Rg,Rb and Rd in Notoginseng Radix et Rhizoma Cream by HPLC Through Nude Mouse Skin

LI Yue-tao; ZHU Li-xia; ZENG Qing; HUANG Guo-zhi

doi:10.11653/syfj2014060106

您当前的位置：

首页 >

文章列表页 >

Study on Transdermal Permeability of Notoginsenoside R, Ginsenoside Rg,Rb and Rd in Notoginseng Radix et Rhizoma Cream by HPLC Through Nude Mouse Skin

更新时间：2024-01-04

- Study on Transdermal Permeability of Notoginsenoside R, Ginsenoside Rg,Rb and Rd in Notoginseng Radix et Rhizoma Cream by HPLC Through Nude Mouse Skin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 6, Pages: 106-109(2014)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2014060106
  CLC：
- Published：2014
- 稿件说明：
移动端阅览
LI Yue-tao, ZHU Li-xia, ZENG Qing, et al. Study on Transdermal Permeability of Notoginsenoside R, Ginsenoside Rg,Rb and Rd in Notoginseng Radix et Rhizoma Cream by HPLC Through Nude Mouse Skin [J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 106-109.
DOI：

LI Yue-tao, ZHU Li-xia, ZENG Qing, et al. Study on Transdermal Permeability of Notoginsenoside R, Ginsenoside Rg,Rb and Rd in Notoginseng Radix et Rhizoma Cream by HPLC Through Nude Mouse Skin [J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 106-109. DOI： 10.11653/syfj2014060106.

摘要

目的：采用高效液相色谱法同步考察三七乳膏中三七皂苷R1、人参皂苷Rg1，Rb1，Rd的体外透皮能力。方法：优选梯度洗脱及检测条件，采用Franz透皮扩散仪进行三七乳膏的裸鼠体外透皮实验，测定三七皂苷R1、人参皂苷Rg1，Rb1，Rd的累积透皮量。结果：建立三七皂苷R1、人参皂苷Rg1，Rb1，Rd的高效液相同步检测方法，体外透皮吸收符合零级速率特征。结论：本研究为三七乳膏的质量控制及临床应用提供依据。

Abstract

Objective: Applying HPLC method to study on the determination of notoginsenoside R1

ginsenoside Rg1

Rb1 and Rd in Notoginseng Radix et Rhizoma cream

and to investigate the ability of percutaneous penetration of Notoginseng Radix et Rhizoma cream. Method: Optimizing the gradient elution conditions and detecting condition. Improved Franz type diffusion cells were used in vitro permeation studies

and nude mouse skin were employed as transdermal barrier.The concentration of notoginsenoside R1

ginsenoside Rg1

Rb1 and Rd in the receptor solution was determined by HPLC to investigate the cumulative permeation quantities at different time respectively. Result: A method for simultaneous determination of notoginsenoside R1

ginsenoside Rg1

Rb1 and Rd by HPLC was established. The percutaneous penetration of Notoginseng Radix et Rhizoma cream conformed to the zero kinetic equation. Conclusion: This method provides the basis for quality control and clinical application of Notoginseng Radix et Rhizoma cream.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Study on in Vitro Percutaneous Absorption of Scald Membrane

Study of Percutaneous Absorption of Ginsenoside Rg in Shangke Spray

Study on Percutaneous Absorption Properties of Colchicine in Fengling Gelatin

Study of Percutaneous Absorption of Strychnine in Shangke Sprays

Percutaneous Absorption of Lappaconitine Micromulsion

Related Author

WANG Rong-juan1

SUN Yuan1

TAN Jia-feng2

LI Rong2

WU Jian1

LI Xue-tao

YUAN Zi-min

CHENG Lan

Related Institution

College of Chinese Medicine,Shanghai University of Traditional Chinese Medicine

Shanghai Zerun Biotechnology Co.Ltd

College of Pharmacy,Liaoning University of Traditional Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰