LIU Bi-wang, XU Kai-xia, GUO Yu, et al. Effect of Selenium Yeast( Fermentation Product) on Diabetes Rat with Immune-suppression[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 136-139.
DOI:
LIU Bi-wang, XU Kai-xia, GUO Yu, et al. Effect of Selenium Yeast( Fermentation Product) on Diabetes Rat with Immune-suppression[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 136-139. DOI: 10.11653/syfj2014060136.
Effect of Selenium Yeast( Fermentation Product) on Diabetes Rat with Immune-suppression
Objective: To study effect of selenium(Se) yeast(Astragalus membranaceus fermentation product) on diabetes rats with immune-suppression. Method: Eighty SD rats
10 to the normal control group
70 rats to establish experimental immune-suppression and diabetic rat model and watch Se yeast on the effects of streptozotocin diabetes and cyclophosphamide immunocompromised rat.The successful model of the animal were randomly divided into 5 groups (n=10 each group): diabetic model with immune-suppression group
oxytetracycline tablets control group (0.1 g·kg-1)
yeast solution group (0.5 g·kg-1)
A.membranaceus extract group (5 g·kg-1)
Se yeast group (0.5 g·kg-1). Each group fixed feed
free drinking water. Four weeks after the last to give the corresponding drug
abdominal aortic blood
separation of serum
fasting blood glucose (FBG)
blood
immunoglobulin (IgG)
interleukin-2 (IL-2)
insulin (INS) level
and pancreatic histological observation and insulin like growth factor (IGF) were detected. Result: In the model group
FBG were significant difference to normal group FBG (P<0.01)
model group INS
WBC
IgG
IL-2 were statistically significant difference to normal group corresponding index (P<0.05). Se yeast group FBG
INS
WBC
IgG
IL-2 have statistical difference to the corresponding index in the model group (P<0.05). Se yeast group with compared other indicators have also improved with the model group. Conclusion: Se yeast can reduce FBG and increase the level of INS
also can enhance the WBC
IgG
IL-2 and other immune parameters
Se yeast can make the immunity of animal models of diabetes mellitus reduce blood sugar
enhance immunity. Extracted from the dregs of decoction of trace elements is a good way to use the development of a drug by fermentation technology.