Regulative Effect of Xiaofeng Xuanqiao Decoction Serum IgE and IL-6,IL-17 in Allergic Rhinitis Guinea Pig

LI Meng; WANG Shou-chuan; WEI Xiao-yun

doi:10.11653/syfj2014060164

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Regulative Effect of Xiaofeng Xuanqiao Decoction Serum IgE and IL-6,IL-17 in Allergic Rhinitis Guinea Pig

更新时间：2024-01-04

- Regulative Effect of Xiaofeng Xuanqiao Decoction Serum IgE and IL-6,IL-17 in Allergic Rhinitis Guinea Pig
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 6, Pages: 164-167(2014)
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- DOI：10.11653/syfj2014060164
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- Published：2014
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LI Meng, WANG Shou-chuan, WEI Xiao-yun. Regulative Effect of Xiaofeng Xuanqiao Decoction Serum IgE and IL-6,IL-17 in Allergic Rhinitis Guinea Pig[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 164-167.
DOI：

LI Meng, WANG Shou-chuan, WEI Xiao-yun. Regulative Effect of Xiaofeng Xuanqiao Decoction Serum IgE and IL-6,IL-17 in Allergic Rhinitis Guinea Pig[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 164-167. DOI： 10.11653/syfj2014060164.

摘要

目的：探讨实验性变应性鼻炎（llergic rhinitis，AR）发病机制中白介素（IL）-6、IL-17和免疫球蛋白E（IgE）水平的变化及其意义，分析消风宣窍汤对这3种细胞因子的调节作用。方法：用卵蛋白（OVA）通过腹腔注射结合滴鼻的方式建立AR豚鼠模型，造模周期共21 d，将60只Hartley豚鼠随机分为正常组、模型组、消风宣窍汤高、中、低剂量组（42，21，10.5 g·kg-1）、氯雷他定组（1.34 mg·kg-1）。用被动皮肤过敏试验（PCA）检验豚鼠模型制备情况，ig治疗1周，ELISA法检测各组血清中免疫球蛋白（IgE）和IL-6，IL-17的水平。结果：与正常组比较，模型组IgE和IL-6，IL-17水平明显升高（P<0.01）；与模型组比较，消风宣窍汤高、中剂量组IgE水平显著降低（P<0.01），IL-6，IL-17水平降低（P<0.05或P<0.01）；低剂量组IgE水平降低（P<0.05）；氯雷他定组IgE水平降低（P<0.05），IL-6，IL-17水平显著降低（P<0.01）。结论：消风宣窍汤降低AR的IgE水平的机制可能是通过降低IgE和IL-6，IL-17水平实现的，并且两者呈正相关关系，提示IL-6和IL-17在AR发病机制中有重要作用。

Abstract

Objective: To investigate the role of immunoglobin E(IgE) and interleukin-6(IL-6)

interleukin-17(IL-17) in the pathogenesis of allergic rhinitis(AR)

and the regulative effect of Xiaofeng Xuanqiao decoction on the above 3 cytokines. Method: AR guinea pig model was established by intraperitoneal injection and intranasal way with ovalbumin (OVA)

and modeling cycle is 21 days. Sixty guinea pigs were randomized into 6 groups:normal control group

AR group

high-dosage

middle-dosage

low-dosage Xiaofeng Xuanqiao decoction group(42

10.5 g·kg-1)

and loratadine group(1.34 mg·kg-1). Passive cutaneous anaphylaxis(PCA) test was performed in all guinea pigs. Xiaofeng Xuanqiao decoction and loratadine were applied to intervene AR guinea pig. The serum levels of IgE and IL-6

IL-17 were determined by enzyme-linked immunosorbant assay(ELISA) method. Result: The expression levels of IgE and IL-6

IL-17 significantly increased compared with the normal group(P<0.01). Compared with that in AR model group

the serum level of IgE in high-dosage Xiaofeng Xuanqiao decoction group significantly was decreased(P<0.01)

the levels of IL-6

IL-17 were decreased(P<0.05);the levels of IgE and IL-6

IL-17 in equivalent-dosage Xiaofeng Xuanqiao decoction group significantly were decreased(P<0.01);the level of IgE in low-dosage Xiaofeng Xuanqiao decoction group decreased(P<0.05)

the levels of IL-6

IL-17 have no obvious changes;the level of IgE in loratadine group decreased(P<0.05)

and the levels of IL-6

IL-17 significantly decreased(P<0.01). Conclusion: Xiaofeng Xuanqiao decoction down-regulate serum level of IgE through decreasing the levels of IL-6 and IL-17

and there is a positive correlation between them

suggesting that IL-6 and IL-17 are important factors in the mechanism of AR.

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