Plasma Pharmacochemistry Study of Effective Extracivet from Kai-xinsan on Alzhemer’s Disease

LIU Xue-wei; LIU Shuang; HUANG Shu-ming

doi:10.11653/syfj2014060179

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Plasma Pharmacochemistry Study of Effective Extracivet from Kai-xinsan on Alzhemer’s Disease

更新时间：2024-01-04

- Plasma Pharmacochemistry Study of Effective Extracivet from Kai-xinsan on Alzhemer’s Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 6, Pages: 179-183(2014)
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- DOI：10.11653/syfj2014060179
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- Published：2014
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LIU Xue-wei, LIU Shuang, HUANG Shu-ming. Plasma Pharmacochemistry Study of Effective Extracivet from Kai-xinsan on Alzhemer’s Disease[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 179-183.
DOI：

LIU Xue-wei, LIU Shuang, HUANG Shu-ming. Plasma Pharmacochemistry Study of Effective Extracivet from Kai-xinsan on Alzhemer’s Disease[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(6): 179-183. DOI： 10.11653/syfj2014060179.

摘要

目的：分析开心散60%乙醇提取物（KXS-60%E）体外各成分的归属来源及大鼠灌服KXS-60%E后药物入血成分。方法：应用UPLC-TOF-MS技术建立KXS-60%E体外成分以及大鼠灌服药物后含药血清样品的分析方法，根据各单味药的色谱峰确定全方主要成分的来源归属；对比空白血清、含药血清的成分异同，分析药物的入血成分。结果：通过对比KXS-60%E与各单味药的正负总离子流图，归属了94个主要色谱峰的来源；大鼠口服KXS-60%E后，在血中分析指定了41个入血成分，其中13个为新产生的代谢产物，28个成分为KXS-60%E的原形成分。结论：血中移行成分及其代谢产物是KXS-60%E防治老年性痴呆（AD）的更直接药效物质基础，对其进行深入的研究将有助于阐明开心散防治AD的作用机制。

Abstract

Objective: To analyse the origin of peaks in Kaixinsan(KXS) extracted by 60% ethano(KXS-60% E)l and the constituents in rat plasma after oral administration of KXS-60% E. Method: A UPLC-TOF-MS method for analyzing the constituents in KXS-60% E and in rat plasma after oral administration of KXS-60% E

has been established.The origin of peaks in KXS-60% E were pointed out compared with each single herb in the formula similarly

the origin of peaks in treated serum after oral KXS-60% E were identified by contrasting the control rat serum. Result: Ninty-four compounds were detected in KXS-60% E in vitro

by compare with control rat plasma

41 peaks were pointed out in treated plasma.Concluding 28 original form in KXS-60% E and 13 metabolites. Conclusion: The constituents absorbed into blood and their metabolites of KXS-60% E were the direct basis of action of the drug

further study on these constituents may clarify the mechanism of KXS prevention and treatment on Alzhemer's disease.

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