Objective: The purpose is to observe the influence of Guizhi Fuling pill and Shenmai san and subtract treatment to chemoradiotherapy after surgery on cervical cancer on recent curative effect

toxic and side effect and immunologic function. Method: Seventy-five cases of patients with cervical cancer chemoradiotherapy treatment were divided into control group (36 cases) and observation group (39 cases). For patients in control group

they took concurrent chemoradiotherapy.Adopt taxol(TAX) and cis-platinum(DDP) as chemotherapy regimens.Based on control group

patients in observation group took Guizhi Fuling pill and Shenmai san add and subtract treatment

1 does/day with conventional water.Both treatments were 12 weeks.During chemoradiotherapy time

two groups were given corresponding support therapy.Observe the tumor size and record toxic reaction by using magnetic resonance imaging (MRI).Processing kamofsky performance status(KPS) score and detecting peripheral blood T lymphocyte subsets(CD3+

CD4+

CD8+

CD4+/CD8+)

serum immunoglobulin(IgG

IgA

IgM) before and after treatment.Supervise the level of polymorphonuclear neutrophil(N) and hemoglobin(Hb). Result: The total effective rate of the observation group on solid tumor was 97.43%

the control group was 86.11%

showing no statistically significant among the two groups

after treatment

the grade of KPS (increasing+stable) of the observation group was 82.05%

superior to 58.33% of the control group(P<0.05)

CD3+

CD4+ and CD4+/CD8+ declining curve

CD8+ was on the increase

CD3+

CD4+ and CD4+/CD8+ of the observation group were higher than the control group

CD8+ was lower than the control group(P<0.05)

there were no obvious changes on IgG and IgA of the control group

IgM declined when compared with that before the treatment

the levels of IgG and IgM of the observation group were higher than the control group (P<0.01). after radiotherapy and chemotherapy

the levels of peripheral blood neutrophils and hemoglobin declined among the both of two groups

and at 4

8 and 12 weeks

the levels of peripheral blood neutrophils and hemoglobin declined of the observation group were higher than the control group (P<0.01)

analyzed by Ridit

the reaction degree of irritation sign bladder of the observation group was lighter than the control group(P<0.05)

besides

myelosuppression

cutaneous reaction and rectal distention stimulation reaction were also lighter than the control group. Conclusion: It can improve patients immune function when Guizhi Fuling pill which combined with Shenmai powder add and subtract treatments were used in concurrent chemoradiotherapy after the cervical cancer operation

and can reduce the side effect

improve the life quality of patients

which deserves promoting in the clinical.