Investigation of  Release of 5-aminosalicylic Acid Colon-specific Osmotic Pump Pellets in Rats

YANG Zhi-xin; XU Zhen; DU Su-mei; CHANG Shuang; YANG Bo

doi:10.11653/zgsyfjxzz2013070001

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Investigation of Release of 5-aminosalicylic Acid Colon-specific Osmotic Pump Pellets in Rats

更新时间：2024-01-04

- Investigation of Release of 5-aminosalicylic Acid Colon-specific Osmotic Pump Pellets in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 7, Pages: 1-6(2013)
- 作者机构：
- 作者简介：
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- DOI：10.11653/zgsyfjxzz2013070001
  CLC：
- Published：2013
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YANG Zhi-xin, XU Zhen, DU Su-mei, et al. Investigation of Release of 5-aminosalicylic Acid Colon-specific Osmotic Pump Pellets in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 1-6.
DOI：

YANG Zhi-xin, XU Zhen, DU Su-mei, et al. Investigation of Release of 5-aminosalicylic Acid Colon-specific Osmotic Pump Pellets in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 1-6. DOI： 10.11653/zgsyfjxzz2013070001.

摘要

目的: 考察基于渗透泵酶触发原理的5-氨基水杨酸(5-ASA)结肠定位微丸的体内释药行为

评价其结肠定位释药特性。方法: 将5-ASA结肠定位微丸(微丸组)与5-ASA羧甲基纤维素钠混悬溶液(对照组)分别给大鼠灌胃

于规定时间间隔从大鼠心脏取血

并取出胃、小肠、盲肠、结肠及其内容物

计算相对靶向释药指数(DDI值);扫描电镜观察不同部位的微丸表面结构。结果: 微丸组在胃、小肠、盲肠、结肠中的DDI值分别为11.09

12.08

187.25

181.68。扫描电镜观察结肠内微丸有清晰可见的孔径。结论: 5-ASA结肠定位微丸具有良好的结肠定位释药性。

Abstract

Objective: To investigate in vivo release behaviour of 5-aminosalicylic acid(5-ASA) colon-specific pellets in rats

which based on osmotic pump enzyme trigger principle

and evaluate its colon localization release characteristics. Method: 5-ASA colon-specific pellets (the pellet group) with 5-ASA sodium carboxymethyl cellulose suspension(the control group) were given to rats by intragastric administration respectively

then got blood from rat heart in predetermined time intervals

and removed the stomach

small intestine

cecum

colon and their contents

relative targeted release index(DDI value) of them were calculated;Pellets' surface structure of different parts were observed by scanning electron microscope. Result: DDI value of the pellets group in the stomach

small intestine

cecum and colon were 11.09

12.08

187.25

181.68

respectively.We could observe that pellets had clearly visible aperture in the colon by scanning electron microscope. Conclusion: 5-ASA colon-specific pellets had good drug release in colon-specific.

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