Optimization of Extraction Technology for  by Central Composite Design/Response Surface Methodology

LIU Ying-xin; LIU Li-li; YU Zu-wen; LI Fei-yan

doi:10.11653/zgsyfjxzz2013070027

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Optimization of Extraction Technology for by Central Composite Design/Response Surface Methodology

更新时间：2024-01-04

- Optimization of Extraction Technology for by Central Composite Design/Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 7, Pages: 27-30(2013)
- 作者机构：
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- DOI：10.11653/zgsyfjxzz2013070027
  CLC：
- Published：2013
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LIU Ying-xin, LIU Li-li, YU Zu-wen, et al. Optimization of Extraction Technology for by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 27-30.
DOI：

LIU Ying-xin, LIU Li-li, YU Zu-wen, et al. Optimization of Extraction Technology for by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 27-30. DOI： 10.11653/zgsyfjxzz2013070027.

摘要

目的: 通过星点设计-响应面法优化厚朴的提取工艺。方法: 以乙醇体积分数、提取时间、溶媒比为自变量

以浸膏得率、厚朴酚及和厚朴酚含量的总评"归一值"为因变量

通过对自变量各水平进行多元线性回归及二项式拟合

采用响应面法优选提取工艺

并进行预测分析。结果: 最佳提取工艺为佳10倍量60%乙醇提取3次

每次95 min。结论: 星点设计-响应面法优选的厚朴提取工艺简便、合理可行

具有较高的精确度

可推广于大生产应用。

Abstract

Objective: To optimize extraction process of Magnolia officinalis by central composite design/response surface methodology. Method: Taking ethanol concentration

extraction time and the amount of solvent as independent variables

overall desirability of dry extract yield and the content of magnolol and honokiol as dependent variable

each level of independent variables was fitted by multiple linear regression and binomial formula fitting

extraction process was optimized by response surface method

and prediction was carried out through comparing the observed and predicted value. Result: Optimum extraction technology was as following:extracted 3 times with 10-fold the amount of 60% ethanol for 95 minutes each time. Conclusion: This optimized extraction technology of M. officinalis was reasonable

stable and feasible with high accuracy

it could be extended to large-scale production applications.

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Related Institution

China National Traditional Chinese Medicine Co. Ltd.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College

Life Science and Technology College,Heilongjiang Bayi Agricultural University

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School of Pharmacy,Traditional Chinese Medicine of Liaoning University

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