Optimization of Extraction Technology for Total Flavonoids in  by Central Composite Design-Response Surface Methodology

ZHU Ming-hui; YIN Hai-bo; WANG Hong-cheng; CHEN Jing; YAO Jia; JIANG Zhong-tao

doi:10.11653/zgsyfjxzz2013070031

您当前的位置：

首页 >

文章列表页 >

Optimization of Extraction Technology for Total Flavonoids in by Central Composite Design-Response Surface Methodology

更新时间：2024-01-04

- Optimization of Extraction Technology for Total Flavonoids in by Central Composite Design-Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 7, Pages: 31-34(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/zgsyfjxzz2013070031
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
ZHU Ming-hui, YIN Hai-bo, WANG Hong-cheng, et al. Optimization of Extraction Technology for Total Flavonoids in by Central Composite Design-Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 31-34.
DOI：

ZHU Ming-hui, YIN Hai-bo, WANG Hong-cheng, et al. Optimization of Extraction Technology for Total Flavonoids in by Central Composite Design-Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(7): 31-34. DOI： 10.11653/zgsyfjxzz2013070031.

摘要

目的: 采用星点设计-效应面法优化老鹳草中总黄酮的醇提取工艺。方法: 以乙醇体积分数、回流时间、溶剂用量和提取温度为自变量

总黄酮得率为因变量

对自变量各水平进行多元线性回归和二项式拟合

通过效应面法优选提取工艺条件

并进行预测分析。结果: 最佳提取工艺为加35倍量65%乙醇于90 ℃提取2次

每次70 min;总黄酮提取率的实测值与预测值偏差-1.25%

二项式拟合复相关系数0.960 9。结论: 优选的醇提工艺稳定简便

且预测性良好。

Abstract

Objective: To optimize extraction technology of total flavonoids in Geranium wilfordii. by central composite design/response surface methodology. Method: Independent variables were ethanol concentration

reflux time

the amount of solvent and reflux temperature

dependent variable was extraction rate of total flavonoids

linear or no-liner mathematic models were used to estimate the relationship between independent variables and dependent variable

response surface methodology was used to optimize extraction technology

and prediction was carried out through comparing the observed and predicted value. Result: Regression coefficients of binomial fitting complex model was as high as 0.960 9

optimal extraction technology conditions were as followings:extracted 2 times with 35 times the amount of 65% ethanol at 90 ℃

70 min per time.Bias between the observed and predicted value was-1.25%. Conclusion: Central composite design/response surface methodology was convenient and highly predictive for optimizing extraction technology of total flavonoids.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Application of CCD-RSM for Optimization of Total Flavonoids Extraction in

Extraction Technology for Total Flavonoids from Fruits of

Optimization of Extraction Technology for by Central Composite Design/Response Surface Methodology

Optimization of Extraction Technology for by Central Composite Design-Response Surface Methodology

Optimization of Extraction Technology for K-CoxB-JN by Orthogonal Test

Related Author

XIE Zhen

CHEN Yong

ZENG Hai-sheng

WEI Tao

LU Sen-hua

XU Bao-li

GUAN Hui-jie

LI Hui

Related Institution

Zhejiang Province Hospital of Traditionl Chinese Medicine

Zhejiang Chinese Medical University

Research Center for Life Science and Environmental Sciences,Haerbin University of Commerce,Haerbin

School of Chinese Materia Medica,Beijing University of Traditional Chinese Medicine

College of Traditional Chinese Medicine,Hebei United University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰